African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

Elizabeth A. Guzman-Hernandez
  • Elizabeth A. Guzman-Hernandez
  • Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación (UIICSE), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México.
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David Segura-Cobos
  • David Segura-Cobos
  • Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación (UIICSE), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México.
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Dante Amato
  • Dante Amato
  • Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación (UIICSE), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México.
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Jose Guillermo Avila-Acevedo2
  • Jose Guillermo Avila-Acevedo2
  • Laboratorio de Fitoquímica, Unidad de Biología, Tecnología y Prototipos (UBIPRO), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México.
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Beatriz Vazquez-Cruz
  • Beatriz Vazquez-Cruz
  • Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación (UIICSE), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México.
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  •  Received: 18 October 2017
  •  Accepted: 10 January 2018
  •  Published: 22 January 2018

References

Aguilar A, Camacho R, Chino S, Jacques P, López E (1994). Plantas medicinales del herbario del IMSS. Cuadros básicos para aparatos y sistemas del cuerpo humano. Instituto Mexicano del Seguro Social. Mexico pp.567. 

View

 

Baharvand-Ahmadi B, Asadi-Samani M (2017). A mini-review on the most important effective medicinal plants to treat hypertension in ethnobotanical evidence of Iran. J. Nephropharmacol. 6(1):3-8.

 

Balam-Ortiz E, Mu-oz-Monroy OE, Rodriguez S, Barajas-Olmos F, Esquivel-Villarreal A, Huerta-Hernandez D, Ojeda-Delgado JL. (2014). Porcentaje de pacientes con hipertensión arterial esencial controlada en dos hospitales de la ciudad de Mexico. Rev. Sanid. Milit. Mex. 68(1):9-14. 

View

 

Bilanda DC, Dzeufiet PDD, Kouakep L, Aboubakar BFO, Tedong L, Kamtchouing P, Dimo T (2017). Bidens pilosa ethylene acetate extract can protect against L-NAME-induced hypertension on rats. BMC Complement. Altern. Med. 17(1):479.
Crossref

 

Blomster RN, Schwarting AE, Bobbitt JM (1964). Alkaloids of Heimia salicifolia I. A preliminary report. Lloydia. 27:15-24.

 

Byrne JA, Malone MH (1981). Protective effects of cryogenine, lythrine and certain derivatives in croton oil induced inflammation. Proc. West. Pharmacol. Soc. 24:183-187. 

View

 

Campos-Nonato I, Hernández-Barrera L, Rojas-Martínez R, Pedroza-Tobías A, Medina-García C, Barquera S (2013). Hypertension: prevalence, early diagnosis, control and trends in Mexican adults. Salud Publica Mex. 55(Suppl 2):S144-S150.
Crossref

 

Go AS, Mozaffarian D, Roger VL Benjamin EJ, Berry JD, Blaha MJ, et al. (2014). Executive summary: heart disease and stroke statistics- 2014 update: a report from the American Heart Association. Circulation 129(3):399-410.
Crossref

 

Godo S, Shimokawa H (2017). Endothelial functions. Arterioscler. Thromb. Vasc. Biol. 37(9):e108-e114. 
Crossref

 

Graham S (1997). Type species: Heimia salicifolia. Archives Kent University, 

View

 

Guzman HE, Segura-Cobos D, De Haro R, Vazquez-Cruz B (2006). Antihypertensive effect of Heimia salicifolia (H.B.K) alkaloids. Pharmacology online 3:3817-3823.

 

Hernández-Abreu O, Torres-Piedra M, García-Jiménez S, Ibarra-Barajas M, Villalobos-Molina R, Montes S, Rembao D, Estrada-Soto S (2013). Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana. J. Ethnopharmacol. 146(1):187-191.
Crossref

 

Kaplan HR, Malone M (1966). Pharmacologic study of nesodine, cryogenine, and other alkaloids of Heimia salicifolia. Lloydia 29:348-359.

 

Kukongviriyapan U, Kukongviriyapan V, Pannangpetch P, Donpunha W, Sripui J, Sae-Eaw A, Boonla O (2015). Mamao pomace extract alleviates hypertension and oxidative stress in nitric oxide deficient rats. Nutrients 7(8):6179-6194.
Crossref

 

Lema WJ, Blankenship JW, Malone MH (1986). Prostaglandin synthetase inhibition by alkaloids of Heimia salicifolia. J. Ethnopharmacol. 15(2):161-167.
Crossref

 

Leo MD, Kandasamy K, Subramani J, Tandan SK, Kumar D (2015). Involvement of inducible nitric oxide synthase and dimethyl arginine dimethylamino hydrolase in Nω-Nitro-L-arginine methyl ester (L-NAME)-induced hypertension. Cardiovasc. Pathol. 24(1):49-55.
Crossref

 

Luna-Vázquez FJ, Ibarra-Alvarado C, Rojas-Molina A, Rojas-Molina I, Zavala-Sánchez MA (2013). Vasodilator compounds derived from plants and their mechanisms of action. Molecules 18(5):5814-5857.
Crossref

 

Magos-Guerrero GA, Santiago-Mejía J, Carrasco OF (2017). Exploratory studies of some Mexican medicinal plants: cardiovascular effects in rats with and without hypertension. J. Intercult. Ethnopharmacol. 6(3):274-279.
Crossref

 

Malone MH, Rother A (1994). Heimia salicifolia: a phytochemical and phytopharmacologic review. J. Ethnopharmacol. 42(3):135-159.
Crossref

 

Raghavan SA, Dikshit M (2004). Vascular regulation by the L-arginine metabolites, nitric oxide and agmatine. Pharmacol. Res. 49(5):397-414.
Crossref

 

Rocha BA, Barroso-Neto IL, Teixeira CS, Santiago MQ, Pires AF, Souza LA, Nascimento KS, Sampaio AH, Delatorre P, Assreuy AM, Cavada BS (2015). CRLI induces vascular smooth muscle relaxation and suggests a dual mechanism of eNOS activation by legume lectins via muscarinic receptors and shear stress. Arch. Biochem. Biophys. 565:32-39.
Crossref

 

Rodrigues AM, Guimarães DO, Konno TU, Tinoco LW, Barth T, Aguiar FA, Lopes NP, Leal IC, Raimundo JM, Muzitano MF (2017). Phytochemical study of Tapirira guianensis leaves guided by vasodilatory and antioxidant activities. Molecules 22(2):E304.
Crossref

 

Rumalla CS, Jadhav AN, Smillie T, Fronczek FR, Khan IA (2008). Alkaloids from Heimia salicifolia. Phytochemistry 69(8):1756-1762.
Crossref

 

Senejouxa F, Girarda C, Aisab HA, Bakrib M, Kerramc P, Berthelota A, Bévalota F, Demougeota C (2012). Vasorelaxant and hypotensive effects of a hydroalcoholic extract from the fruits of Nitraria sibirica Pall. (Nitrariaceae). J. Ethnopharmacol. 141:629-634.
Crossref

 

Sousa GJ, Oliveira PWC, Nogueira BV, Melo AF Junior, Faria TO, Meira EF, Mill JG, Bissoli NS, Marcelo P (2017). Fructose intake exacerbates the contractile response elicited by norepinephrine in mesenteric vascular bed of rats via increased endothelial prostanoids. J. Nutr. Biochem. 48:21-28.
Crossref

 

Su KH, Lin SJ, Wei J, Lee KI, Zhao JF, Shyue SK, Lee TS (2014). The essential role of transient receptor potential vanilloid 1 in simvastatin-induced activation of endothelial nitric oxide synthase and angiogenesis. Acta. Physiol. 212(3):191-204.
Crossref

 

Syeda AA, Lahiria S, Mohanb D, Valicherla GR, Gupta AP, Riyazuddin M, Kumar S, Maurya R, Hanif K, Gayen JR (2016). Evaluation of anti-hypertensive activity of Ulmus wallichiana extract and fraction in SHR, DOCA-salt- and L-NAME-induced hypertensive rats. J. Ethnopharmacol. 193:555-565.
Crossref

 

Tirapelli CR, Ambrosio SR, de Oliveira AM, Tostes RC (2010). Hypotensive action of naturally occurring diterpenes: a therapeutic promise for the treatment of hypertension. Fitoterapia. 81(7):690-702.
Crossref

 

Wang Y, Zhang F, Liu Y, Yin S, Pang X, Li Z, Wei Z (2017). Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in L-NAME-induced hypertensive rats. Clin. Exp. Hypertens. 39(7):628-639.
Crossref

 

World Health Organization (WHO) (2013). A global brief on hypertension: silent killer, global public health crisis. Document number: WHO/DCO/WHD/2013.2. pp.1-40.

 

Xua Z, Wang X, Dai Y, Kong L, Wang F, Xu H, Lu D, Song J, Hou Z (2010). (+/-)-Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis. Chem. Biol. Interact. 186(2):239-246.
Crossref

 

Yam MF, Tan CS, Ahmad M, Shibao R (2016). Vasorelaxant action of the chloroform fraction of Orthosiphon stamineus via NO/cGMP pathway, potassium and calcium channels. Am. J. Chin. Med. 44(7):1413-1439.
Crossref

 

Zhang W, Han Y, Meng G, Bai W, Xie L, Lu H, Shao Y, Wei L, Pan S, Zhou S, Chen Q, Ferro A, Ji Y (2014). Direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats. J. Am. Heart. Assoc. 3(1):e000606.
Crossref

 

Ziberna L, Kim JH, Auger C, Passamonti S, Schini-Kerth V (2013). Role of endothelial cell membrane transport in red wine polyphenols-induced coronary vasorelaxation: involvement of bilitranslocase. Food Funct. 4(10):1452-1456.
Crossref