African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2250

Full Length Research Paper

Anti-fertility activity of aqueous root bark extracts of Asparagus africanus Lam and Annona senegalensis Pers combination on female Sprague Dawley rats

Okidi Oscar P. Okello
  • Okidi Oscar P. Okello
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Mbarara University of Science and Technology, Uganda.
  • Google Scholar
Nkwangu David
  • Nkwangu David
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Mbarara University of Science and Technology, Uganda.
  • Google Scholar
Joseph Oloro
  • Joseph Oloro
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Mbarara University of Science and Technology, Uganda.
  • Google Scholar


  •  Received: 11 November 2014
  •  Accepted: 17 September 2018
  •  Published: 08 February 2019

References

Debella AJ, Hasliger EJ, Kunert OJ, Michl G, Abebe D (1999). Steroidal Saponins from Asparagus africanus. Phytochemistry 5(8):1069-1075. 
Crossref

 

Desta B (1993). Ethiopian traditional herbal drugs, part II. Antimicrobial activity of 63 mechanical plants. Journal of Ethnopharmacology 39(2):129-139. 
Crossref

 

Evans WC (2009). Trease and Evans Pharmacognosy. 16th edition W.B. Saunders London.

 

Farnsworth NR (1975). Potential value of plants as source of new antifertility agents. Journal of pharmaceutical sciences 64(4):535-598. 
Crossref

 

Giannitrapani L (2006). Sex hormones and risk of liver tumor. Annals of the New York Academy of Sciences 1089(1):228-236.
Crossref

 

Kahlenborn C (2006). Oral contraceptive use as a risk factor for pre-menopausal breast cancer: a meta-analysis. Mayo Clinic Proceedings 81(10):1290-1302.
Crossref

 

Khanna U, Chaudhari RR (1968). Antifertility screening of plants part-1; Investigation of butea monosperma (lam) kutze, Indian Journal of Medical Research 56:1575-79.

 

Kong YC, Lau CP, Wat KH (1989). Antifertility principle of Ruta graveolens. Planta medica 55(2):176-178.
Crossref

 

Lorke D (1983). A new approach to acute toxicity testing. Arch Archives of toxicology 54(4):275-287.
Crossref

 

More G, Tshikalange TE, Lall N, Botha F, Meyer JJM (2008). "Antimicrobial activity of medicinal plants against oral microorganisms. Journal of Ethnopharmacology 119(3):473-477. 
Crossref

 

Msonthi JD, Magombo D (1983). Medicinal Herbs in Malaria and their Uses. Hamdard 20(2):94-100.

 

Muanza DN, Kim BW, Euler KL, Williams L (1994). "Antibacterial and antifungal activities of nine medicinal plants from zaire. International Journal of Pharmacognosy 32(4):337-345 
Crossref

 

Mukund D, Dinesh D, Varsha Z, Manik D (2012). Documentation of Fertility Regulatory Ethnomedicinal Plants Used by Tribal's of Yavatmal's District Maharashtra, India. International Journal of Scientific and Research Publications 2(3):2250-3153.

 

NIH (1978). Guide for the Care and Use of Laboratory Animals (Revised). NIH Publication No. 83-32.

 

Okoye TC, Akah PA, Omeke CP (2010). "Evaluation of the anticonvulsant and muscle relaxant effects of the methanol root bark extracts of Annona senegalensis," Asian Pacific Journal of Tropical Medicine 3(1):25-28.
Crossref

 

Okoye TC, Akah PA (2010). "Anticonvulsant and sedative effects of root bark extract and fractions of Annona senegalensis," Inventi Impact 1(2):100-104.

 

Okoye TC, Akah PA, Ezike AC, Nwoye JC (2011). "Studies on the effects of Annona senegalensis root bark extract on acute and chronic inflammation in rats," Journal of Pharmacy Research 4(5):1443-1444.

 

Oliver B (1960). Medicinal Plants in Nigeria. Ibadan, Nigeria: Nigerian College of Art, Science and Technology P 19.

 

Padmashali B, Vaidya VP, Vagdevi HM, Satyanarayana ND (2006). Antifertility Efficacy of the Plant Balanites Roxburghii (Balanitaceae) in Female Rats. Indian journal of pharmaceutical sciences 68(3).

 

Rad JS, Alfatemi SMH, Rad MS, Sen DJ (2013). Phytochemical and antimicrobial evaluation of the essential oils and antioxidant activity of aqueous extracts from flower and stem of Sinapis arvensis American Journal of Advanced Drug Delivery 1(1):001-010.

 

Ramya R, Sivasakthi R, Senthilkumar C, Anudeepa J, Santhi N, Venkata RN (2011). Preliminary Phytochemical and Antifertility Studies on Dodonea viscose Linn, Asian Journal of Research in Pharmaceutical Science 1(3):77-79.

 

Sharifi RJ, Hoseini ASM, Sharifi RM, Iriti M (2013). In-vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus aureus. Ancient Science of Life 33:107-11.
Crossref

 

Sharifi RJ, Hoseini ASM, Rad MS, Iriti M (2014a). Free radical scavenging and antioxidant activities of different parts of Nitraria schoberi l. Journal of Biologically Active Products from Nature 4(1):44-51.
Crossref

 

Sharifi-Rad J, Miri A, Hoseini-Alfatemi SM, Sharifi-Rad M, Setzer WN, Hadjiakhoondi A (2014b). Chemical Composition and Biological Activity of Pulicaria vulgaris Essential Oil from Iran. Natural Product Communications 9(11):1633-1636. PMID: 25532299

 

Shibeshi Workineh, Eyasu Makonnen, Asfaw Debella and Legesse Zerihun (2006). Phytochemical, contraceptive efficacy and safety evaluations of the methanolic leaves extract of Achyranthes aspera l. in rats. Debrezeit, Ethiopia. Pharmacologyonline 3:217-224.

 

Suleiman MM, Dzenda T, Sani CA (2008). "Antidiarrhoeal activity of the methanol stem-bark extract of Annona senegalensis pers. (Annonaceae).Journal of ethnopharmacology 116(1):125-130 
Crossref

 

Uganda Bureau of Statistics (UBOS) and ICF International, Uganda Demographic and Health Survey 2011, Kampala, Uganda: UBOS; and Calverton, MD, USA: ICF International, 2012.

 

Watt JM, Breyer-Brandwijk MG (1962). The Medicinal and Poisons Plants of Southern and Eastern Africa. 2nd edition. Edinburgh and London, U.K.: E abnd S Livingstone Ltd.