African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 15 January, 2013; 7(2)

January 2013

Effect of cisplatin on glutathione redox status in isolated plasma and cytosolic fraction

Cisplatin has been used therapeutically in the treatment of malignant tumors. Meanwhile, the major limitations associated with cisplatin are its side effects in the form of nephrotoxicity, neurotoxicity, emetogensis and emerging resistance. Most of these problems are due to its adverse effects on the body’s endogenous cytoprotective molecules like glutathione (GSH). In current study, the effect of glutathione on...

Author(s): Kifayatullah Shah, Muhammad Farid Khan, Amir Badshah, Syed Umer Jan, Arshad Farid, Hadia Bibi and Haroon khan

January 2013

The effect of adding hyoscine to vaginal misoprostol on shortening the time of abortion induction

Induced abortion is the termination of pregnancy by medical or surgical methods before the fetus’ viability. Available evidences show that due to spasmolytic effects, use of Hyoscine with Misoprostol may reduce the pain during abortion induction. The aim of this study is to evaluate the effect of Misoprostol in combination with Hyoscine compared with Misoprostol alone in reducing the duration...

Author(s): Ezzatalsadat Haji Seid Javadi, Samira Ghaffari, Farideh Movahed, Amir Javadi and Omid Mashrabi

January 2013

Effect of diabetan on blood glucose, glycosylated hemoglobin, lipid profile, liver and kidney function tests of diabetic patients: A clinical, double blind, randomized trial

Considering the side effects of insulin and oral hypoglycemic agents, this study was performed with the aim of investigating the hypoglycemic effect of Diabetan (glycogol) tablet, which is a blend of Saliva officinalis, Trigonella foenum and ginseng. A double-blind clinical trial was carried out on type-2 diabetic patients who were referred to the Endocrine and Metabolism Clinic of Shahrekord...

Author(s): Behradmanesh Mohammad-Saeed, Ahmadi Mohammad-Ali, Rafieian-kopaei Mahmoud

January 2013

Polymorphism in glutathione S-transferase P1 (GSTP1) on the effect of epirubicin or doxorubicin chemotherapy among breast cancer

To investigate the glutathione S-transferase P1 (GSTP1) expression with chemotherapy polymorphisms involved in the prognosis of breast cancer patients with epirubicin or doxorubicin chemotherapy among breast cancer. 219 primary breast cancer patients who were consecutively recruited in our study have been treated with anthracycline-based (epirubicin [E] or doxorubicin [A]) chemotherapy between March 2006 and March 2007....

Author(s): Xueying Zhang, Mingying Li, Helin Wang, Wenyi Niu, Zhenxuan Wu, Guangcan Shi, Jianmiao He and Jieqing Wu

January 2013

Therapeutic antiepileptic drug monitoring pattern in a tertiary care hospital in Oman

In epilepsy, therapeutic drug monitoring (TDM) could aid in individualizing dosage regimen and ascertaining compliance on anti-epileptic drugs (AEDs). The aim of this study was to survey the requests for TDM of AEDs to determine drugs involved, observed concentrations, reasons for requests and action undertaken. TDM requests for AEDs were surveyed at a university hospital in Oman from January 2006 to December 2009. A...

Author(s): Mohammed Al Za’abi, Abdullah Al Asmi, Rowayda Ahmed, Safiya Al-Masrouri, Rihab Al-Lawati, Ramachandiran Nandhagopal and Ibrahim Al-Zakwani

January 2013

Chemical composition, antimicrobial activity, antioxidant and total phenolic content within the leaves essential oil of Artemisia absinthium L. growing wild in Iran

Water-distilled essential oil from the leaves of Artemisia absinthium L. collected from Ardabil, north-western Iran, was analyzed by Gas chromatography and mass spectrometry (GC and GC-MS). In the leaf oil of A. absinthium, 19 components, which represented 100% of the total composition were identified. 1,8-Cineole (36.46%), borneol (25.99%) and camphor (10.20%) were the major components in this oil. The leaves of A....

Author(s): Mahboubeh Taherkhani, Abdolhossein Rustaiyan, Iraj Rasooli and Tofigh Taherkhani