African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Table of Content: 15 June, 2012; 6(22)

June 2012

Precautionary measurements and rationale use of antibiotics in diabetic foot ulcer can save amputation: A case report

Diabetic foot is one of the major and most frequently occurring complications of diabetes mellitus (DM). There are many underlying factors for the development of diabetic foot ulcer. Among these factors poor supply of blood to lower extremities due to increase peripheral resistance in blood vessels (PVD), presence of Ischemia, infection or trauma to foot. The present case report is under discussion to rationalize the...

Author(s): Ashfaq Ahmad, Amer Hayat Khan, Mohammad Atif, Muhammad Ihtisham Umar, Haroon Khalid Syed, Nadia Shamshad Malik and Atif Usman

June 2012

Chemistry, pharmacology and medicinal properties of Peganum harmala L.

Peganum harmala L. is known as Syrian rue, Wild rue and Harmal. P. harmala extracts are considered important for drug development, because they are reported to have numerous pharmacological activities in the Middle East, especially in Iran and Egypt. For a long time P. harmala has been used in traditional medicines for the relief of pain and as an antiseptic agent. P. harmala also...

Author(s): Jinous Asgarpanah and Fereshteh Ramezanloo

June 2012

Iron supplementation during pregnancy and birth weight

In this controlled prospective and longitudinal study, we explored among 92 pregnant women, the probable correlation between the epidemiological and socio-economic factors and the installation of anaemia. We were also interested in the effect of the iron supplementation on the modifications of the hematological parameters among anaemic pregnant women, the gestational age and the weight of the newborn...

Author(s): Demmouche A. and Moulessehoul S.

June 2012

Intervention to improve the knowledge of sexually transmitted infections (STIs) and syndromic management among community pharmacists in Lagos state, Nigeria

Sexually transmitted infections (STIs) remain a public health problem in most parts of the world. The syndromic management approach is based on an STI syndrome and it offers many benefits in the struggle against STIs. Community pharmacists are one of the most accessible and trusted health care professionals. They are well located to reach millions of individuals with STI prevention and control messages and other...

Author(s): Aina Bolajoko Ajoke and Adetuyi Chioma Clare

June 2012

Effects of bisphosphonates on bone metabolism and serum matrix metalloproteinase level in patients with ankylosing spondylitis secondary osteoporosis

The aim of the study is to investigate the effects of bisphosphonates on bone metabolism and serum matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-3 (MMP-3) levels in patients with ankylosing spondylitis (AS) secondary osteoporosis. 60 patients with AS secondary osteoporosis were divided into treatment group and control group. The control group was given conventional treatment of oral calcium D-dimensional,...

Author(s): Haijun Xiao, Liancheng Shan, Haiming Zhu and Feng Xue

June 2012

Non-medical anabolic-androgenic steroid consumption and hepatitis B and C virus infection in regular strength training practitioners

The aim of this study is to analyse the use of non-medical anabolic-androgenic steroids (AAS) among Brazilian regular strength training practitioners and evaluate the prevalence of hepatitis B (HBV) and hepatitis C virus (HCV) infection among currently AAS injectors. The survey was addressed to 893 adult healthy males and regular strength-training practitioners from Northeast region of Brazil. Self-reported AAS users...

Author(s): Paulo Adriano Schwingel, Helma Pinchemel Cotrim, Crimério Ribeiro dos Santos Junior, Bernardo Cruz Rios Salles, Carlos Eduardo Romeu de Almeida and Cláudio Cesar Zoppi

June 2012

Evaluation of Viburnum grandiflorum for its in-vitro pharmacological screening

In the present study the crude ethanolic and its succeeding solvent fractions of the aerial and roots parts of Viburnum grandiflorum were investigated for their in-vitro pharmacological (antifungal, phytotoxic and insecticidal) profile. In case of antifungal activity the n-hexane fraction was active against Microsporum canis having 35% zone of inhibition and ethyl acetate fraction were...

Author(s): Muhammad Alam, Ghiasuddin, Anwar Sadat, Naveed muhammd, Ashfaq Ahmad Khan and Bina S. Siddiqui

June 2012

Effect and mechanism of Shao-Yao Gan-Cao Tang on adjuvant-induced arthritis in rats

Shaoyaogancao-tang (SGT) is a widely used traditional medical formula to relieve different types of pain in China. Here, we investigated the suppressive effect of SGT on rat adjuvant-induced arthritis (AA) and the underlying mechanism. Paw swelling and histological score were calculated during or after SGT treatment. Levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and...

Author(s): Gang Chen, Ping Jia and Xue Gao

June 2012

A simple and novel method for preparing the taste masking levofloxacin microsphere suspension

A taste masking levofloxacin resinate microsphere suspension was prepared. At first, levofloxacin-resinates were prepared by both bath and column methods in HCl solution (0.01 mol/L) before they were used as cores to prepare the suspension. The drug loading amount in the drug resinates made by bath method and column method was 33.2 ± 0.8 and 45.7 ± 0.6% (n =...

Author(s): Xiaofeng Yu, Hongfei Liu, Changshan Sun, Shuangshuang Shi, Xiao Fu and Yan He

June 2012

Exploration of the biological basis of coronary heart disease angina pectoris with Qi deficiency and Qi stagnation based on GenCLiP gene mining software

The aim of this study is taking coronary heart disease (CHD) angina pectoris (AP) as an example to approach the manipulation and application of GenCLip, gene mining software in searching disease-syndrome related genes. According to results from CIPHER, a prediction software, 100 genes were predicted based on the similarity of the characterization of CHD. GenCLiP gene mining...

Author(s): Xueling Ma#, Xing Zhai#, Yubo Li, Yulin-OuYang, Qi Shi, Hua Xie, Huihui Zhao, Shuzhen Guo, Yong Wang, Jianxin Chen and Wei Wang