African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Table of Content: 15 November, 2012; 6(42)

November 2012

Hepatoprotective and antioxidant activity of Spilanthes paniculata flower extracts on liver damage induced by paracetamol in rats

The present study was undertaken to investigate the antioxidant and hepatoprotective effect of Spilanthes paniculata Wall. ex DC flower extracts against paracetamol-induced liver damage. The study was conducted in 36 male Wistar rats of either sex, and six groups were established. While the first group was maintained as normal control (NC, distilled water), Groups 2 to 6 were administered 3 g/kg Paracetamol...

Author(s): Syed Ayaz Ali, Shukla Mahanand, Subur W. Khan

November 2012

Chemical composition, antibacterial and antioxidant activities of a new essential oil chemotype of Algerian Artemisia arborescens L.

The aim of the present study is to investigate the chemical composition, antibacterial and antioxidant activities of three essential oils extracted by hydrodistillation from the aerial parts ofArtemisia arborescens L., which was collected from three different regions near Tlemcen city in the West Northern of Algeria: Beni Snous, Bidar and Chetouane. The chemical composition was investigated using both capillary gas...

Author(s): Kawther Younes, Salima Merghache, Nassim Djabou, Djamila  Merghache, Alain Muselli, Boufeldja Tabti and Jean Costa

November 2012

An optimal establishment of an acute hyperglycemia zebrafish model

Recently, zebrafish has shown the potential to become an important in vivo model for diabetes-related research. In this study, we performed a validation study for the establishment of optimal hyperglycemia involving the following factors: alloxan concentrations of 100, 200, 300, and 400 mg/100 ml; exposure times of 30, 60, 120, and 180 min to an alloxan solution and water glucose solution; and water glucose...

Author(s): Eunji Shin#, Bin Na Hong,# and Tong Ho Kang

November 2012

Biological screening of ethyl acetate extract of Hedera nepalensis stem

Hedera nepalensis is commonly used in folk medicines for the treatment of cough and other human ailments; therefore it was selected for phytochemical and antimicrobial screening. Its phytochemical screening showed the presence of different classes of secondary metabolites. The ethyl acetate extract of its stem showed the presence of steroids, terpenoids, saponins and flavonoids. Terpenoids and flavonoids were...

Author(s): Ghias Uddin, Ashfaq Ahmad Khan, Muhammad Alamzeb, Saqib Ali, Mamoon-Ur-Rashid Anwar Sadat, Muhammad Alam, Abdul Rauf and Wali Ullah

November 2012

Complex system entropy method of Professor Kong Guangyi’s experience in the treatment of menstrual disease

This study used data mining technology to study Professor Kong Guangyi’s medication experience for the treatment of menstrual period. 612 treatments of the medical records of the menstrual period of the patients of Professor Kong Guangyi were collected and data mining technology was used to study his prescribed drug. For single herb, frequency statistical method was used; in association between paired...

Author(s): Tiegang LIU, He YU, Jingwei LIU, Wang ZHANG,Longyun XU, Guokai LV and Xiaohong GU

November 2012

Appropriateness of digoxin level monitoring in a children's hospital

To evaluate the proportion of inappropriate digoxin level determinations in children at Children’s Hospital of Fudan University. A retrospective analysis of 291 digoxin level determinations in 210 inpatients was performed. Appropriateness criteria were based on existing criteria that were revised using local expert opinion. The main outcome measure was the proportion of digoxin levels assessed as inappropriate by...

Author(s): Yue Huang, Di Cao and Zhiping Li

November 2012

Relationship among C-reactive protein, iron status, oxidative stress, and pulmonary tuberculosis

This study aims to assess the effects of acute tuberculosis and drug treatment on oxidative stress markers [malondialdehyde (MDA) and total antioxidant status (TAS)], C-reactive protein (CRP), and body iron index. A total of 20 patients with active tuberculosis (treatment group) and 50 healthy subjects (control group) were selected. MDA, TAS, serum CRP, serum iron, serum total iron binding capacity, transferrin...

Author(s): Bing Sun, Yaqin Yang, Fang Ren, Qingjiang Wang, Junwei Cui, Jinhe Shi and Xiuqin Cui

November 2012

Potential drug targets prediction for H1N1 influenza A based on protein-protein interaction networks

In this paper, some proteins were determined as potential drug targets for H1N1 influenza A. These proteins were found using three steps: i) determining a set of human proteins that had interactions with the proteins of H1N1 virus, and assigning a weight to each protein; ii) mapping the set of human proteins into the human protein-protein interaction networks; iii) combining the topological properties of the network and...

Author(s): Di Chen#, Xi Liu#, Chang Chen, Lin Chen, Yibo Gao, Jianqiang Yi, Shihuan Tang, Peng Lu and Hongjun Yang

November 2012

Prediction of polymorphisms in DNA repair genes on the prognosis of bone tumors with methotrexate, intravenous adriamycin and intra-arterial cisplatin chemotherapy

We investigate the relationship of SNPs in XRCC1, ERCC1 and ERCC2 to methotrexate intravenous adriamycin and intra-arterial cisplatin chemotherapy response and survival in bone cancer patients. 281 consecutive patients diagnosed with bone tumor between January 2003 to January 2005, and they were followed up until the end of January 2010. Polymorphisms in XRCC1Arg280His, XRCC1Arg399Gln, ERCC1 Asn118Asn, ERCC1 Gln504Lys,...

Author(s): Yan Zhao# Yuan Zuo#, Yong-jian Sun and Hong-jun Huo

November 2012

Association study between the human resource of pharmacy and SCI dissertation

With the development of scientific researches in China, more and more domestic researchers have their research results published in overseas journals, especially those that are indexed by Science Citation Index. There are great progresses in the field of Traditional ChineseMedicine, and many research results are published in the journals indexed by Science Citation Index. Hence, the Science Citation Indexed...

Author(s): Shengyun Ding, Kuo Gao, Liangtao Luo and Kaifeng Liu