April 2014
Evaluation of clarithromycin pharmacokinetics after single and repeated oral administration of atorvastatin in hyperlipidemic Wistar rats
The present study was aimed to evaluate the clarithromycin pharmacokinetics after atorvastatin single and repeated dose administration in induced hyperlipidemic Wistar rats. A high fat diet (2% cholesterol) was used to induce hyperlipidemia and feed was given to rats for 6 to 8 weeks. Group allocation was as follows: G1 to G3: induced hyperlipidemic rats pretreatment of atorvastatin as a single dose followed by...
April 2014
Discriminating power of dissolution medium in comparative study of solid dispersion tablets of Biopharmaceutics Classification System class 2 drug
In vitro dissolution testing should discriminate between the impact of excipients on release profile of Biopharmaceutics Classification System class 2 drugs. Among the four batches of carvedilol solid dispersion tablets, SDT-2-L containing 30% w/w mannitol and 2.5% w/w L-hydroxypropyl cellulose LH-11 exhibited least mean dissolution time in gastric buffer (pH = 1.2) and phosphate buffer (pH = 6.8). However,...
April 2014
Ameliorating effects of thymoquinone in rodent models of schizophrenia
The present study was carried out to evaluate the role of thymoquinone (TQ) in animal models of schizophrenia. TQ (20 mg/kg, intraperitoneally) was administered daily for 28 days in mice. Different models of schizophrenia such as haloperidol-induced catalepsy, apomorphine-induced climbing behaviour and elevated plus maze test were used. After the last dose of TQ on the 28th day, behavioural tests were performed followed...
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