November 2014

Extracts of Gongronema latifolium and Vernonia amygdalina improve glycaemia and histomorphology of testes of diabetic Wistar rats

This study aimed to assess the histomorphological and glycaemic effects of the ethanolic leaf extracts of Vernonia amygdalina (VA) and Gongronema latifolium (GL) on the testis of alloxan-induced diabetic Wistar rats. Forty male Wistar rats were divided into two groups A and C; the former served as negative control group received normal saline, while the later was the diabetic group. This group was further divided into...

Author(s): O. O. Azu, I. A. Edagha, A. I. Peter, I. Umoh and U. Abia

November 2014

Pharmacotoxic evaluation of extracts of medicinal plants used in the treatment of obesity

Medicinal plants are rich sources of bioactive compounds with potential for therapeutic, cosmetic and food use, and many of them are consumed only based on popular use, without any scientific proof of their efficacy and safety. The objective of this study was to evaluate the toxic and pharmacological effects of aqueous extracts of the plant species Aloe vera (L.) Burm., Simaba ferruginea St. Hil., Baccharis trimera...

Author(s): anderson Assaid Simão, Angelita Duarte Corrê, Paulo Sérgio Castilho Preté, estela de rezende Queiroz, Pedro Henrique Souza Cesar, Carlos Henrique de Moura Oliveira and silvana Marcussi

November 2014

Formulation of propranolol hydrochloride controlled release tablets: Effect of surfactant charge and mechanisms of drug release

Controlled release drug formulation is a very important branch in pharmaceutical industry and attracts a lot of research and investments. Eudragit RL100 and sodium carboxymethylcellulose (NaCMC) are used in drug formulation due to their good coating properties. Here, we studied propranolol hydrochloride formulation with anionic polymer Eudragit RL100 alone and with other additives (lactose, sorbitol, dextrose). The...

Author(s): Hassan A. Alhmoud, Ehab I. El-Hallous, Nasser E. Ibrahim, Attia O. Attia,and ElDessoky S. Dessoky,