African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 28 February, 2013; 7(8)

February 2013

Effects of allopurinol and melatonin on warm renal ischemic- reperfusion injury in dogs

It has been previously observed that reperfusion of ischemic kidneys produces much more damage than that caused by the period of ischemia alone. However, the nature of the cellular insult that produces these changes is unknown. In this study, 30 male domestic native dogs were selected and randomly divided into five groups (n=6): G1:sham-operated(sham)(n=6), G2:ischemic-reperfusion induced group(I/R); about 45 min...

Author(s): NeshatGharamaleki Mehrdad, Shahbazi MohammadAmin, and Safarmashaei Saeid

February 2013

Justifying the use of the bluish liquid from the African giant snail (Achatina marginata) in traditional male circumcision surgery in Western Nigeria

In contemporary African tradition, the male child is circumcised. One of the requirements for successfully carrying out this surgical feat by the traditional birth attendants in the western part of Nigeria is to immediately bath the exposed penis surface with the fresh bluish liquid from the African giant snail (Achatina marginata). This study screened the bluish liquid for anti-bacteria/anti-fungi activities and...

Author(s): S. O. Olagbende-Dada, A. A. Adeniyi, F. O. Adefolaju, A. Adepoju-Bello and M. O. Ologunagba

February 2013

Effects of Juniperus phoenicea extract on uricemia and activity of antioxidant enzymes in liver, erythrocyte and testis of hyperuricemic (oxonate-treated) rats

The aim of the present study was to determine whether administration of Juniperus phoeniceaextract would have any advantage over allopurinol therapy on (1) lipids peroxidation level and (2) antioxidant activity in liver, erythrocyte and testis of hyperuricemic rats by oxonate administration. In hyperuricemic rats, levels of lipids peroxidation in liver, erythrocyte and testis were found to be significantly...

Author(s): Nesrine GDOURA, Jean-Claude MURAT, Abdelwaheb ABDELMOULEH and Abdelfattah ELFEKI

February 2013

Lavender aromatherapy massages in reducing labor pain and duration of labor: A randomized controlled trial

Labor pain is a challenging issue for midwifes and designing intervention protocols. Aromatherapy is one of the non-pharmacological methods for pain relief and Lavendula has analgesic properties. The aim of this study was to investigate the effect of aromatherapy massage with Lavender oil. This was a prospective, randomized, controlled trial that was conducted in 2008 at Mahdeeh Hospital of Tehran University, Tehran,...

Author(s): Abbaspoor Zahra and Mohammadkhani Shahri Leila

February 2013

Goldcrest honey and its solvent extracts: A natural product with anti-Helicobacter pylori activity

This study evaluates the anti –Helicobacter pylori activity of Goldcrest honey at 10, 20, 50 and 75% v/v concentrations as well as its extracts (n-hexane, diethyl ether, chloroform and ethyl acetate) using the agar well diffusion technique. The minimum inhibitory concentrations (MIC50) of the two most active extracts were determined by the broth microdilution assay and MICs were read by enzyme-linked...

Author(s): Christy E. Manyi-Loh, Roland N. Ndip, and Anna M. Clarke

February 2013

Influence of naringin on the myocardial ultrastructure and NF-κB expression in rats with diabetic cardiomyopathy

We investigated the effects of naringin on myocardial nuclear factor-kappa B (NF-κB) expression in rats with diabetic cardiomyopathy (DC), and its protective effect on DC. Wistar rats were randomly assigned into a normal control group, DC group and naringin intervention group. The DC rat model was established using high-sugar, high-fat feeding and streptozotocin (STZ) injection. The ultrastructural changes in the...

Author(s): Keng Wu, Qiong You and Yan-Ming Tu

February 2013

Function of human insulin-like growth factor-1 (hIGF-1) transgene towards the regeneration of peripheral nerves in vivo

The aim of this study was to investigate the function of human insulin-like growth factor-1 (hIGF-1) transgene in vivo towards the regeneration of peripheral nerves. Thirty (30) male Wistar rats were randomly grouped after the sciatic nerve regeneration chamber model was set up. The hIGF-1 Treatment Group (TG) was injected the mixed solution of pcDNAhIGF-1 and LipfectAmine (hIGF-1 DNA was 4 ug) immediately at the spot...

Author(s): Jia-Xiang Gu, Nai-Chen Zhang, Hong-Jun Liu, Jun-Bo Pan, Heng Tian, Wen-Zhong Zhang and Jing-Cheng Wang

February 2013

Preparation and characterization of toltrazuril polyethyleneglycol 6000 solid dispersions with improved solubility

The current study investigated toltrazuril/polyethyleneglycol 6000 solid dispersions (toltrazuril/PEG6000 SDs) with improved solubility. The SDs were prepared by solvent-melting method with PEG 6000 as carrier. It was validated by differential thermal analysis (DTA) and cumulative dissolution rate. The solubility of toltrazuril, physical mixture and SDs were measured. The ultra violet (UV) spectrophotometer method was...

Author(s): Haixia Lǜ and Suying Ma

February 2013

Antioxidant, anti-cholinesterase and antibacterial activities of the bark extracts of Garcinia hombroniana

This study reports an antioxidant, anti-cholinesterase, antibacterial activities and total flavonoids content of different extracts (water, methanol, ethyl acetate, dichloromethane andn-hexane) of the bark of Garcinia hombroniana. The antioxidant activity was evaluated using radical scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing...

Author(s): Jamila Nargis, Khairuddean Melati, Choon-Sheen Lai, Osman Hasnah, Keng-Chong Wong, Murugaiyah Vikneswaran and Kooi-Yeong Khaw

February 2013

Effects of leptin on colorectal cancer cell line HT-29

The purpose of this study was to investigate the effect of leptin on the growth of HT-29 colorectal cancer cell line. HT-29 cells were treated with leptin at several concentrations of 0, 5, 50, 100, 200 ng/ml, respectively. Epidermal growth factor (EGF) was taken as the positive control. The effect of leptin on the growth, proliferation and apoptosis of HT-29 colorectal cancer cell line was assayed through drawing...

Author(s): Ying Wang, Yan Liao, Hong-gang Yu, and He-sheng Luo,

February 2013

Toxicological evaluation of zerumbone on antitumor effects in mice

Zerumbone (ZER), a bioactive compound isolated from Zingiber zerumbet Smith, was examined for single and repeated-dose toxicity at dosages with antitumor effects on imprinting control regions (ICR) mice and mice of either sex for repeated dose, respectively. For the single dose toxicity study, ZER was administrated to ICR mice at a dose of 500 mg/kg via intraperitoneal injection, while for the repeated...

Author(s): Yeung Bae Jin, Woo-Duk Seo, Yoon-Jin Lee, Yun-Sil Lee and Hae-June Lee

February 2013

Antidiarrheal activity of methanol extract and major essential oil contents of Saussurea lappa Clarke

Earlier folklore claims reveal that Saussurea lappa Clarke (family Asteraceae) is used in the treatment of abdominal pain, dysentery and chronic skin diseases. This species has a good economic potential as its essential oil is commercially valuable in the flavour and fragrance industry. The major bioactive components of S. lappa are costunolide and dehydrocostus lactones. However, other...

Author(s): J. S. Negi, V. K. Bisht, A. K. Bhandari, V. P. Bhatt, M. K. Sati, J. P. Mohanty and R. C. Sundriyal,