African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2199

Table of Content: 29 December, 2011; 5(24)

December 2011

Antifungal effect of the extract of propolis on the growth of three species of Epidermophyton flucosum, Trichophyton violaseum and Trichophyton tonsorans in laboratory environment

Cutaneous infections in human include a wide variety of diseases. Most of these infections are caused by dermatophytes and the resulting disease is called dermatophytosis. Dermatophytosis brings many problems for human hence, studies and new researches about this disease can be useful in controlling it with fewer side effects. So, in this study the antidermatophytal features of propolis of bee were tested. In this test,...

Author(s): Shahin Gavanji, Mohammad Javad Asgari, Ramin Vaezi and Behrouz Larki

December 2011

Anti-angiogenic effect of Spica prunellae extract in vivo and in vitro

Angiogenesis is a fundamental component of cancer growth and metastasis; therefore, inhibition of angiogenesis has become a promising strategy for the discovery and development of cancer chemotherapeutics. Recently, natural products have attracted significant interest as therapeutic agents for cancer since they have relatively fewer side effects as compared to modern chemotherapeutics and have long been used clinically...

Author(s): Wei Lin, Liangpu Zheng, Jinyan Zhao, Qunchuan Zhuang, Zhenfeng Hong, Wei Xu, Youqin Chen, Thomas J. Sferra, and Jun Peng

December 2011

Anti-diabetic effects of walnut oil on alloxan-induced diabetic rats

Diabetes arises from a deficient production of insulin by the ß-cells of the pancreatic islets. Many traditional treatments have been recommended in the alternative system of medicine for treatment of diabetes mellitus; however, the mechanism of most of the herbs used has not been defined. This study was carried out to clarify the effect of walnut (Juglans regia) oil on blood glucose and their possible effect on...

Author(s): Parivash Rahimi, Najmeh Kabiri, Sedigheh Asgary and Mahbubeh Setorki

December 2011

Clinical and histopathologic impacts of indomethacin on healing of experimental gum injuries on rabbits

Indomethacin is one of the old non-steroidal anti-inflammatory drugs and it inhibits cycloxygenase I and II. The objective of this research is to study the clinical and histopathological effect of indomethacin which is usually used in surgery as an analgesic drug and which is evaluated on the process of healing of surgical wound. We selected 15 New Zealand white rabbits with the same condition and after numbering, they...

Author(s): Ali Rezaie, Ehsan Sepehrizadeh, Samad Rezaie, Gafor Mosavi and Mehrdad Nazeri

December 2011

Novel antimalarial agent (Cinnamic 3β-hydroxyolean-12-en-28-carboxylic anhydride): Synthesis, characterization and in vivo studies

The search for potent antimalarial agent has led to the synthesis of a novel hybrid molecule, cinnamic 3β-hydroxyolean-12-en-28-carboxylic anhydride (JH26). The structure was confirmed using 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. The in vivo antimalarial evaluation of the compound JH26 in mice inoculated with the malaria parasite (Plasmodium berghei berghei) was studied after 5 days (D5)...

Author(s): J. D. Habila, F. O. Shode,  G. I. Ndukwe, J. O. Amupitan and A. J. Nok

December 2011

Pharmacodynamic properties of essential oils from Cymbopogon species

Pharmacodynamic research plays an important role in the development of new antibacterial agents. Characterization of this pharmacodynamic can be used to design the best dose and dosing strategy for clinical trials. The pharmacodynamic properties can be determined by studying the bactericidal activity and the postantibiotic effects (PAE). Measurements of both bactericidal activity and the lag time could be useful in...

Author(s): M. F. Mohd Fazrullah Innsan, M. Hairul Shahril, M. S. Samihah, O. Siti Asma, S. Mat Radzi, A. K. Abd Jalil and M. N. Hanina

December 2011

Effects of recombinant MAP30 on cell proliferation and apoptosis of human esophageal carcinoma EC-1.71 cells

Momordica anti-HIV protein of 30 kDa (MAP30) was found to have anti-tumor activities. Therefore, in the present study the effects of MAP30 on the proliferation and apoptosis of human esophageal carcinoma EC-1.71 cells were investigated. The antiproliferative activities were determined using methyl thiazolyl tetrazolium (MTT) assay, colony formation and tumor xenograft model of nude mice. Morphological changes were...

Author(s): Yan-Jun Xue, Xiao-Hong Han, De-yu Chen, He Huang, Xian-Qian Li and Shi-He Shao

December 2011

Preparation and characterization of human malignant melanoma ganglioside ScFv antibody conjugated quantum dot probe

Melanoma is a highly aggressive and deadly skin cancer. Few treatment options are available for patients with metastatic melanoma, and the global incidence of melanoma is increasing faster than that of other cancers. Therefore, it is vitally important to uncover and use genetic and epigenetic regulatory mechanisms at work during the development and progression of melanoma for better prevention, diagnosis and clinical...

Author(s): Xiaomin Zhang, Tangde Zhang, Bing Wang, Nina Tang, Ledong Sun and Quan Luo

December 2011

Importance of white flowered Mirabilis jalapa with respect to its phytochemical and antimicrobial screening

The aqueous and ethanolic extract derived from the leaves of white flowered plant of Mirabilis jalapa L. were screened for antibacterial activities against Staphylococcus aureus, Salmonella typhi, Escherichia coli, Vibrio cholerae and Bacillus subtilis. Aqueous extracts did not display any inhibition to the tested bacteria. However, all the ethanolic extracts showed good antibacterial activity...

Author(s): Naveed Ullah, Mir Azam Khan, Haider Ali, Nouman Altaf, Shakoor Ahmad, Ghayour Ahmed and Minhaj ud Din

December 2011

Triterpenes from the stem bark of Protorhus longifolia exhibit anti-platelet aggregation

Two triterpenes were isolated from the chloroform extract of Protorhus longifolia. Theirstructures were established through spectral analysis (nuclear magnetic resonance (NMR), infrared (IR), liquid chromatography mass spectrometry (LC-MS)) as 3-oxo-5α-lanosta-8,24-dien-21-oic acid (1) and 3β-hydroxylanosta-9,24-dien-24-oic acid (2). The two triterpenes were screened for their antioxidant,...

Author(s): Rebamang A. Mosa, Adebola O. Oyedeji, Francis O. Shode, Mogie Singh and Andy R. Opoku