African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 29 October, 2013; 7(40)

October 2013

Antioxidant studies of various solvent fractions and chemical constituents of Potentilla evestita Th. Wolf

In the present research work acacetin (1), chrysin (2) and umbelliferone (3) were isolated for the first time from the chloroform fraction of Potentilla evestita. The isolated compounds as well as various solvent fractions of the crude ethanolic extract were assessed for their antioxidant potentials. A significant DPPH free radical scavenging effect was observed in the methanolic and chloroform fractions. The acacetic...

Author(s): Abdur Rauf , , Rehan Khan and Naveed Muhammad

October 2013

Gastroprotective activity of mirtazapine, escitalopram and venlafaxine in depressed rats

The study investigated the gastro-protective effects of certain antidepressants in relation to ranitidine on indomethacin-induced ulcer in depressed rats. Animals were divided into 6 groups (n = 8). Induction of depression was done by clonidine (0.8 mg/kg; i.p.) for 10 days in all groups except the 1st one (normal control). Depressive-like behavior was confirmed by increased immobility time in forced swimming test....

Author(s): Sally A. El-Awdan and Hala F. Zaki

October 2013

Evaluation of the reversibility and possible mechanisms of antifertility of Catha edulis F. (khat) extract following subacute administration in rodents

The study of antifertility mechanisms of khat can be used to counteract the possible toxicities during pregnancy as abuse of khat is common in all segments of female population. The present study was initiated to assess the reversibility of antifertility effect and to evaluate the possible mechanisms of antifertility of the chloroform diethyl ether extract of Catha edulis. K300 exhibited significant decrease in the mean...

Author(s): Seyfe Asrade, Workineh Shibeshi and Ephrem Engidawork

October 2013

Evaluation of biologic effects of an Ilex paraguariensis aqueous extract on the labeling of blood constituents with technetium-99m and on the morphology of red blood cells

Ilex paraguariensis (mate-tea) has been used to treat type-2 diabetes and emphysema. This tea presents antioxidant activity and promotes satiety, body weight lowering and improves bone mineral density. Blood constituents have been labeled with technetium-99m (99mTc) and this labeling depends on the presence of a reducing agent. Stannous chloride has been widely utilized with this purpose. The influence of natural and...

Author(s): Ana Cristina S. Braga, Maria Luisa Gomes, Josefina da Silva Santos, Joelma Fonseca de Oliveira, Lúcia de Fátima Amorim, Gláucio Diré Feliciano, Sebastião David Santos-Filho and Mario Bernardo- Filho