African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 29 October, 2014; 8(40)

October 2014

Development and validation of simple and rapid high performance liquid chromatographic method for routine analysis of human insulin in formulations

A simple, specific, precise and accurate reversed phase liquid chromatographic (RP-LC) method has been developed for determination of insulin in dosage form. The chromatographic separation was achieved on a Symmetry® RP-C18, (150 × 4.6 mm, 5 μm) column at a detector wavelength of 214 nm and a flow rate of 1.0 ml/min. Mobile phase comprised of 55 volume of 1 mmol sodium sulphate in high performance liquid...

Author(s): Mohammad Javed Ansari, Shahid Jamil, Mohammad Khalid Anwer, Ramdhan Al-shdefat and Bahaeldin Elsyed Ali

October 2014

An alternative capillary electrophoresis method for the quantification of caspofungin in lyophilisate powder and its measurement uncertainty

Recently, the use of capillary electrophoresis (CE) methods in pharmaceutical practice has gradually increased. Moreover, measurement uncertainty has been used to guarantee the traceability and the reliability of analytical results obtained. The aim of this work was to develop and validate a CE method for the quantification of caspofungin in lyophilised powder for injection, as well as to study the main sources of...

Author(s): Daniela Dal Molim Ghisleni, Rogério Takao Okamoto, Felipe Rebello Lourenço and Terezinha de Jesus Andreoli Pinto

October 2014

Investigation of zoledronic acid induced stress on rabbit kidneys with oxidative stress markers

In this study, we aimed to investigate the effect of zoledronic acid, which is  a potent  bisphosphonate  on  oxidative stress  markers in rabbit kidney tissue. As an oxidative stress marker, malondialdehyde, nitric oxide, glutathione were studied. Rabbits were given daily 100 μg/kg zoledronic acid for 28 days (n = 7) in the study group. Control group (n = 7) rabbits were fed ad libitum for...

Author(s): Şimay Gürocak⊃, Mehmet Gül, Ercan Karabulut, Tugba Raika Kıran and Aysun Bay Karabulut