African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2126

Table of Content: 29 September, 2011; 5(12)

September 2011

Does essential oil of Carum copticum affect acetylcholine-induced contraction in isolated rat's Ileum?

Our previous study demonstrated that aqueous extract of Carum copticum reduced contraction activity of rat’s ileum; this study was conducted to examine the effect of essential oil from C. copticum on acetylcholine induced contraction in isolated rat's ileum. In experimental procedures, the tissue samples were suspended from the transducer lever, mounted in the organ bath containing...

Author(s): Seyed Hassan Hejazian–Y, , Houri Sepehri, Mohammad Hossein Dashti-R,  Seyed Majid Mahdavi, Seyyed Majid Bagheri, Abbas Morshedi, Mohammad Ebrahim Rezvani, Seyed Abid Ali and Mohammad Shaiq Ali

September 2011

Effects of zinc supplementation on hematological parameters of high performance athletes

The purpose of the present study is to determine the effect of eight weeks zinc supplementation on the erythrocyte and leukocyte counts and other hematological parameters in male kick boxers. Twenty-four subjects were included in the study. They were equally divided into three groups as follows: Group EZ, training and receiving 2.5 mg/kg zinc supplement per day; Group SZ, receiving the zinc supplement but no training...

Author(s): Yahya Polat

September 2011

The effect of twelve week aerobic exercise programme on health related physical fitness components and blood lipids in obese girls

The aim of this study was to investigate the effects of 12 week aerobic exercise program on health related fitness components and blood lipids in obese girls. In this study, a total of 40 girls were recruited as exercise group (n = 20) and control group (n = 19). Participants joined sessions for 60 min per day, 3 days per week for 12-week. There were significant differences  in weight, body mass index (BMI),...

Author(s): Özcan Saygın and Mehmet Ali Öztürk

September 2011

The healing effect of Lactobacillus plantarum isolated from Iranian traditional cheese on gastric ulcer in rats

Probiotics are living organisms which upon ingestion in certain numbers exert health benefits beyond inherent basic nutrition. The lactic acid bacteria are one of the most significant groups of probiotic organisms. These bacteria are commonly used in fermented dairy products and have been advocated for the treatment of gastrointestinal disorders. The aim of the present study is to investigate the effect of a probiotic...

Author(s): Mitra Heydari Nasrabadi, Helia Aboutalebi, Maryam Tajabadi Ebrahimi and Farima Zahedi

September 2011

Catechin-enriched green tea extract as a safe and effective agent for antimicrobial and anti-inflammatory treatment

The aim of this study was to examine the mechanism of green tea in treating a broad spectrum of human diseases and to develop a safe and effective agent for antimicrobial and anti-inflammatory application. Catechin-enriched green tea extract (CEGTE) was prepared containing 83.15 ± 0.79% of total catechins. In vitro antimicrobial and in vivo anti-inflammatory effects were investigated and...

Author(s): Y. F. Wang, S. H. Shao, P. Xu, X. Q. Yang and L. S. Qian

September 2011

Department of Tea Science, Zhejiang University, Hangzhou 310058, P. R. China.

To investigate the regulatory role of RhoA/Rho kinase in the effects of fluvastatin (Flu) on the tumor necrosis factor-α (TNF-α) induced expression of tissue factor (TF) in human umbilical vein endothelial cells (HUVECs) which may provide basis for the prevention of arterial thrombosis, HUVECs in logarithmic phase were divided into TNF-α group, Flu group and TNF-α+Flu group. enzyme-linked...

Author(s): Wei-hong Jiang, Kan Yang , Hong Yuan , Li-ping Peng , Li-hua Tan , Yun-zhong Guo and Fang-ping Chen

September 2011

Hypolipidemic and antioxidant activities of avocado fruit pulp on high cholesterol fed diet in rats

Avocado, Persea americana Mill. (Lauraceae) is a widely consumed fruit in many countries for its nutritional and medicinal benefits. In the present study, avocado fruit pulp (AFP) was investigated for its anti-hyperlipidemic and antioxidant activities in Wistar albino rats. Hyperlipidemia in the animal was induced by feeding high cholesterol diet (HCD) for 70 days in standard chow diet. Rats on HCD showed...

Author(s): Mohammed S. Al-Dosari

September 2011

Seeking colorectal carcinoma related genes based on regulation network

Colorectal carcinoma (CRC) is one of the most frequent cancers worldwide with very high mortality. In this study, the microarray data was used to construct a regulation network to identify potential genes related with CRC. The results showed SP1, RELA, STAT1, PPARA and TP53 arise as hub nodes in transcriptome network in accordance with previous studies, and new transcription factors and target genes related with CRC...

Author(s): Tiejian Yang#, Peng Lu#, Yu Zhang, YingBin Zheng, Lixia Wang, Lihua Zhou and Jialin Liu   #These authors contributed equally.

September 2011

Pharmacoepidemiological studies of prescribing practices of health care providers of Pakistan: A cross-sectional survey

Half of all medicines are prescribed or sold inappropriately and half of all patients fail to take their medicines correctly worldwide. The present study was conducted to evaluate the pattern and practice of drugs within the modern medical system by investigating the prescription pattern, drug use in private and public health care facilities, assessment of the magnitude of the problem, identifying factors...

Author(s): Shahzad Hussain, Farnaz Malik, Abdul Hameed, Ghazala Parveen, Fahadya Yasin Raja, Humayun Riaz, Shazia Shafaat, Amina Wajid and Rafique Ahmad Channa

September 2011

Evaluation of Bauhinia variegata L. bark fractions for in vitro antioxidant potential and protective effect against H2O2-induced oxidative damage to pBR322 DNA

Bauhinia variegata L. (Fabaceae) is widely used in Indian traditional medicine. The present study was undertaken to evaluate the protective effect of different fractions from the crude methanolic extract of B. variegata L. bark against free radicals and H2O2-induced oxidative damage to pBR322 DNA. 80% methanol extract (MEB) of the bark was fractionated into non-polar fractions, including hexane (HEB),...

Author(s): Neha Sharma, Renu Bhardwaj, Subodh Kumar and Satwinderjeet Kaur

September 2011

Extracorporeal ultrasound-guided high intensity focused ultrasound therapy: Present limitations

Extracorporeal ultrasound-guided high intensity focused ultrasound (USgFU) ablates solid lesions non-invasively. Limitations manifested in preclinical and clinical trials are discussed in brief. The ablation efficiency (necrosis rate) is low. Tissue responses are monitored in real time during USgFU treatment, based upon the appearance of hyperecho within the insonated volume. However, hyperecho does not necessarily...

Author(s): Tinghe Yu, and Ping Huang

September 2011

New antimicrobial peptides purified directly from Bullacta exarata

Endogenous antimicrobial peptides are exciting candidates as new antibacterial agents due to their broad antimicrobia spectra, highly selective toxicities and the difficulty for bacteria to develop resistance to these peptides. Marine invertebrates, which rely solely on innate immune system for host defense, are the spectacular resources for new antimicrobial compounds. In order to seek for new effective...

Author(s): Ma Jian-yin, Guo Xiao-mian, Hu Jun-feng and Wang Xian

September 2011

Co-expression of citrulline-nitric oxide cycle enzymes and decreased glutamine synthetase expression in different regions of brain in epilepsy rat model

The aim of this study was to determine the mRNA expression of nitric oxide synthetase (NOS, argininosuccinate synthetase (AS), argininosuccinate lyase (AL) and glutamine synthetase (GS) in different regions of brain in rats subjected to kainic acid (KA) mediated epilepsy. The short term (acute) group animals were sacrificed after 2 h and the long term (chronic) group animals were sacrificed after 5 days of single...

Author(s): Mummedy Swamy, Wan Roslina Wan Yusof, Intan Nurfirdaus Mat Zin, K. N. S. Sirajudeen, Zulkarnain Mustapha and Chandran Govindasamy

September 2011

Development and validation of a stability indicating high-performance liquid chromatography (HPLC) method for the estimation of isoniazid and its related substances in fixed dose combination of isoniazid and ethambutol hydrochloride tablets

A stability indicating high-performance liquid chromatography (HPLC) method has been developed and validated for the determination of isoniazid and its related substances of isonicotinic acid and isonicotinamide in fixed dose combination of isoniazid and ethambutol HCl tablet. Inertsil, C-18, 250 × 4.6 mm, 5 m HPLC column with a mobile phase of potassium dihydrogen phosphate buffer of pH 6.9...

Author(s): J. Ayyappan,  P. Umapathi   and S. Darlin Quine

September 2011

Phytotoxic and antibacterial assays of crude methanolic extract of Mentha longifolia (Linn.)

Mentha longifolia (Horse Mint; syn. M. sylvestris L.) is a well known species in the genusMentha (mint) widely applied in medicine as a constituent of various drugs, and is often used in aromatherapy. The current study was designed to investigate the antibacterial and phytotoxic capacity of methanolic extract of M. longifolia. Five hundred gram of shade dried whole plant in powdered form...

Author(s): Rahmat Ali Khan, Faridullah Khan, Mushtaq Ahmed, Abdus Sabur Shah, Noor Aslam Khan, Muhammad Rashid Khan and Mir Sadiq Shah.

September 2011

Effect of Ocimum basilicum on apoptosis in testis of rats after exposure to electromagnetic field

Medicinal use of basil, Ocimum basilicum, dates to ancient times in Iran, China and India. This herb has been used since ancient times as a medicine and food and it is known that the antioxidant effect of O. basilicum is beneficial to spermatogenesis, so it was hypothesized that this herb might also provide protection to sperm parameters. Male Wistar rats (n = 40) were allocated to four groups, a control...

Author(s): Arash Khaki, Fatemeh Fathiazad, Mohammad Nouri and Amir Afshin Khaki

September 2011

Evaluation of anticandidal potential of Quercus baloot Griff. using contact bioautography technique

The activities of fractions derived from hydroalcoholic extract of Quercus baloot leaves against a dimorphoic pathogenic yeast, Candida albicans (Cl. I. 4043) was evaluated. The hydroalcoholic extract was sequentially fractionated to give n-hexane, dichloromethane, ethylacetate, and n-butanol fractions, which were also subjected to qualitative phytochemical analyses. Preliminary anticandidal...

Author(s): Muhammad Khurram, Abdul Hameed, Muhammad Usman Amin, Wajeeha Manzoor, Naseem Ullah, Kamran Ahmad Chishti, Sahibzada Umar Khayyam, Muhammad Hassan and Abdul Qayum

September 2011

A modified arithmetical method of Reed and Muench for determination of a relatively ideal median lethal dose (LD50)

Reed L.J. and Muench H. introduced arithmetical method for determination of median lethal dose (LD50) in 1938. Since then the same method has not been revised for better precision and accuracy. Therefore this paper examined the possibility of modifying the method and arrived at logical conclusion. The possible modifications involve calculating per cent of test animals both that died and survived at all the test dose...

Author(s): Saganuwan Alhaji Saganuwan

September 2011

Hysterectomy versus GnRH agonist for dysfunctional uterine bleeding in premenopausal women

Dysfunctional uterine bleeding (DUB) in premenopausal women is a common problem leading to medical or surgical intervention. The aim of this study was to compare GnRH agonist and hysterectomy in treatment of DUB in premenopausal women. In a randomized clinical trial, 250 patients of age, 40 to 55 years with complaint of abnormal uterine bleeding resistant to routine medications were enrolled into the study. Ninety seven...

Author(s): Elaheh Ouladsahebmadarek, Manizheh Sayyah-Melli, Mehri Jafari, Morteza Gojazadeh and Arash Khaki

September 2011

Antitumour effects of Scutellaria barbata ethanol extracts in mice transplanted with human hepatocellular carcinoma (HepG2) cells

Scutellaria barbata, also known as “Banzhilian”, is one of the commonly used Chinese medicinal herbs. The objective of this study was to examine the antitumour activities of ethanol extract prepared from S. barbata in mice transplanted with human hepatocellular carcinoma (HepG2) cells lines, and to test proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), CD31 in...

Author(s): Chen Bendong, Ning Mingliang, Zhou Wenyan, Zou Lili and Yu Songning

September 2011

“Tai Chi Quan” exercise used in improving the heart function of aged people

In this study, we assessed the effect of “Tai Chi Quan” exercise on heart function of aged people. A total of 66 old people (mean age, 72.81 ± 7.27 years) was recruited for the study in November 2009. All subjects were asked to practice “Tai Chi Quan” for one hour, every day. This study had continued for 1 year. Some physiological indexes were measured in November 2009 (beginning...

Author(s): Yin Haili, Liu Fenghu and Jiang Juan