African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 29 September, 2013; 7(36)

September 2013

Quercetin improves antioxidant response in diabetes through maintenance of reduced glutathione levels in blood

Oxidative stress is involved in development of diabetes and its complications. Quercetin has shown to have antioxidant activity against oxygen free radicals and the ability to induce a better antioxidant response in healthy animals. The aim of the present study was to investigate the effect of daily administration of quercetin, in two different doses, on the levels of reduced glutathione (GSH) and lipid peroxidation in...

Author(s): Mariza Olvera Nájera, Imelda Silvar Tinajero, Lorena I. Rodriguez Páez, Sergio E. Meza Toledo and José L. Muñoz Sánchez    

September 2013

Characterization and controlled release of gentamicin from novel hydrogels based on Poloxamer 407 and polyacrylic acids

Parenteral administration of gentamicin, a hydrophilic aminoglycoside antibiotic commonlyused in the control of Gram positive and Gram negative infections, is limited by adverse effects such as nephrotoxicity, ototoxicity and neurotoxicity. In this study, topical hydrogels of gentamicin were produced using three polymeric hydrogels of Poloxamer 407 and polyacrlic acids...

Author(s): Petra Obioma Nnamani, Franklin Chimaobi Kenechukwu, Chidinma L. Anugwolu, Agubata Chukwuma Obumneme and Anthony Amaechi Attama    

September 2013

Galenic formulation and antimicrobial activities of tablets made from essential oil of Lippia multiflora Moldenke (Verbenaceae)

Essential oil-containing tablets made from essential oil of Lippia muItiflora Moldenke have been developed with an intention to treat buccal and pharyngeal infections after perlingual administration. Tablets were accomplished with Arabic gum, mannitol and L. multfloraessential oils (2.5‰ w/w) and tested for antimicrobial activity using agar dilution techniques. The tablets were...

Author(s): Daouda Toure, Armand Koffi and Adèle Kacou-N’Douba    

September 2013

Factor I mutation in Tunisian patient with atypical hemolytic uremic syndrome

Atypical hemolytic uremic syndrome or the Shiga toxin-producing Escherichia coli (STEC) negative hemolytic uremic syndrome (HUS) is a rare disorder typically classified as familial or sporadic. Recent literature has suggested that approximately 50% of patients have mutations in factor H (CFH), factor I (CFI), or membrane cofactor protein (encoded by CD46). Importantly, results of renal transplantation in...

Author(s): Nadia Leban, Sabra Aloui, Dalel Touati, Donia El Hayek, Habib Skhiri, Gerard Lefranc, Abdellatif Achour, Mezri Elmay, Jemni Chibani and Amel Haj Khelil    

September 2013

Bioassay guided isolation and characterization of anti-microbial and anti-trypanosomal agents from Berberis glaucocarpa Stapf.

Different fractions of Berberis glaucocarpa Stapf were tested for their antibacterial and anti-trypanosomal properties using the well established Alamar blueTM 96 well microplate assays. Then eight known compounds (1 to 8), including five alkaloids (1 to 5), were isolated and characterized from this plant for the first time. All the compounds were tested for their antimicrobial and antitrypanosomal...

Author(s): Muhammad Alamzeb, M. Rafiullah Khan, Saqib Ali, Mamoon-Ur-Rashid and Ashfaq Ahmad Khan    

September 2013

Counterfeit drugs in Nigeria: A threat to public health

The production of counterfeit drugs is a broad and under reported problem particularly affecting poorer countries. It is an important cause of unnecessary mortality and morbidity, and loss of public confidence in medicines and health structures. Empirical observations show that there may be more counterfeit than genuine drugs in circulation. This article discusses the prevalence of counterfeit drugs in Nigeria. It...

Author(s): Olusegun Akinyandenu