African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 8 April, 2014; 8(13)

April 2014

Quantification of propranolol in rat plasma by LC-MS/MS using tramadol as an internal standard: Application to pharmacokinetic studies in TAA-induced liver fibrotic rats

A simple, rapid and selective liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is developed and validated for quantification of propranolol without the sample extraction step in rat plasma using tramadol as an internal standard (IS). The analytes are separated using an isocratic mobile phase which consist of methanol and 10 mm ammonium formate (70/30, v/v) on an isocratic UK-C18 (Imtakt Unison 2.0...

Author(s): Hyun-Ku Kang, Min-A Kang, Hyun-Jin Kim, Yoo-Sin Park, Shin-Hee Kim, Do-Wan Kim and Ju-Seop Kang

April 2014

Surfactants solubility, concentration and the other formulations effects on the drug release rate from a controlled-release matrix

Surfactant effects on the drug release from controlled release systems have been widely studied. These effects are dependent on the surfactant physical properties such as structure, charge, solubility and concentration. In addition, presence of excipients in the matrices can modify the surfactants effects. Here we investigated the effects of surfactant solubility and concentration of excipients on the drug release. Two...

Author(s): Hassan A. Al-Hmoud, Nasser E. Ibrahim, and Ehab I. El-Hallous,