African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2157

Table of Content: 8 February, 2015; 9(5)

February 2015

Formulation, optimization and characterization of candesartan cilexetil nanosuspension for in vitro dissolution enhancement

According to Biopharmaceutical classification system (BSC), candesartan cilexetil (CC) is a class-II drug which has limited bioavailability mainly due to its low solubility. In order to enhance its solubility, a universal approach of making nanosuspension is been used in the present investigation. High pressure homogenization, controlled precipitation, media milling and high speed homogenization are the various...

Author(s): Mahesh R. Dabhi, Umang K. Ghodasara, Dhaval D. Mori, Kalpesh A. Patel and Ravi Manek, and N.R. Sheth

February 2015

Muscarinic activity of aqueous leaves extract of Excoecaria grahamii Stapf 1913 on rabbit blood pressure and toad isolated perfused heart

Excoecaria grahamii, African shrub, is used in many West African countries traditional medicine against different diseases as powerful purgative and biopesticide. There is little work about pharmacological effects of this plant because of its high toxicity. The effects of the aqueous extract of the plant was investigated on rabbit blood pressure and toad isolated and perfused heart activity. E. grahamii extracts (EGE)...

Author(s): Youssoufou Ouédraogo, Raymond Gourounga Belemtougri and Anankpètinan Prosper Dabiré

February 2015

Ethnobotanical survey of anticancer plants in Askira/Uba local government area of Borno State, Nigeria

Ethnobotanical survey was conducted on anticancer plants in Askira/Uba local government area of Borno State, Nigeria. Administration of questionnaires and oral interviews to 20 traditional medicine practitioners (TMPs) and field trip were carried out in the study area. A total of 65 different plants belonging to 41 families were identified during the survey. Six plants belong to the Caesalpinioideae, 5 from Fabaceae, 4...

Author(s): Saidu Ibrahim Ngulde, Umar Kyari Sandabe and Isa Marte Hussaini

February 2015

Physicochemical characterization of lapachol

The aim of this study was to characterize three batches of lapachol (LAP), in order to establish specifications for the development of pharmaceutical forms. Physical methods including nuclear magnetic resonance (1H and 13C NMR), infrared spectroscopy (IR), scanning electron microscopy (SEM), x-ray diffraction, differential scanning calorimetry (DSC), determination of the melting range and drug assay were performed. All...

Author(s): Maria Alice Maciel Tabosa, Elayne Karine Souto de Melo, Karoline Belém Seixas, Isabelle Moura Fittipaldi de Souza Dantas, Davi Pereira de Santana and Leila Bastos Leal

February 2015

Methanolic extracts from roots and cell suspension cultures of Waltheria americana Linn induce GABA release in cerebral slices of mouse brain

This study evaluates and compares the release of the neurotransmitter γ-aminobutyric acid (GABA) induced by methanolic extracts obtained from roots of wild plants and from cell suspension cultures of W. americana Linn. The release of this neurotransmitter was evoked by crude and fractioned extracts derived from both roots of wild plant and cell suspension cultures, tested at three concentrations: 10, 50 and 100...

Author(s): Jorge Mundo, Patricia Castillo-España, María del Carmen Gutiérrez Villafuerte, Carolina Abarca Camacho, Ismael León- Rivera, Jesús Arellano-García and Irene Perea-Arango