African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 8 June, 2013; 7(21)

June 2013

Dissolution rate enhancement of bicalutamide by adsorption process

The aim of the present research was to enhance the dissolution rate of poorly water soluble drug, bicalutamide by adsorption process. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carrier like povidone K30 and adsorbent like magnesium aluminum silicate were used as dissolution rate enhancers. Granules of bicalutamide were prepared...

Author(s): M. V. Srikanth, B. Janaki Ram, D. Senthil Rajan, G. Adinarayana and K. V. Ramana Murthy

June 2013

Biochemical and hematological alterations associated with intravenous administration of double doses of non-ionic contrast media in anesthetized dogs

To monitor the effects of a double dose of non-ionic contrast agent administered intravenously (iv) to anesthetized dogs, on the major functions and the biochemical and hematological parameters, two non-ionic contrast agents were tested (Optiray 350 and Ultravist 370) on two lots of 15 adult male and female dogs. The administered dose was 7 ml/kg and the recommended dose was 3.5 ml/kg. Several biochemical and...

Author(s): Papuc Ionel, Lacatus Radu, Purdoiu Robert Cristian and Pavaloiu Alexandra Nicoleta

June 2013

Therapeutic effect of a Chinese herbal compound on spontaneous lupus MRL/lpr mice

This study aimed to assess the therapeutic effects of Wu-Di-Tang (WDT) on lupus prone MRL/lpr mice and provide an experimental basis for clinical applications. Thirty-two female MRL/lpr mice were randomly assigned to treatment and control groups, 16 in each group. Oral administration of WDT and saline to treated and control mice began from 12 weeks of age and continued for 16 weeks. The efficacy of WDT was evaluated by...

Author(s): Suqin Zhang#, Peifeng Wei#, Miqu Wang and Bin Wu

June 2013

Assessment of frequently accessible homeopathic mother tinctures for their pharmacopoeal specifications in Pakistan

The homeopathic system of medicine has attained ample attentiveness being one of the premium systems of cure accessible to mankind, and lingers to hold the awareness of remedial publications and the correspondence at the same time. The foremost superlative of cure is swift, undeviating refurbishment of health or inhibitive of the disease in its entire scope, most trustworthy and non detrimental way. The probable means...

Author(s): Farnaz Malik, Shahzad Hussain, Kazi Muhammad Ashfaq, Sobia Tabassam, Anzar Ahmad, Rashid Mahmood and Sidra Mahmood

June 2013

Antioxidant ability of squid ink polysaccharides as well as their protective effects on deoxyribonucleic acid DNA damage in vitro

Squid ink polysaccharides (SIPS) were isolated from squid ink, a plentiful and multifunctional marine material, and were demonstrated to have amelioratory effects on cyclophosphamide-induced damage in internal organs of model animals by our previous reports. To further investigate the protective effects of SIPS on chemotherapeutic damage caused by cyclophosphamide, this paper evaluated the bioactivities of the marine...

Author(s): Ping Luo  and Huazhong Liu 

June 2013

Toxic and some essential metals in medicinal plants used in herbal medicines: A case study in Pakistan

The levels of some heavy metals in eight different medicinal plant samples along with soils were collected from two different locations from salt range of Punjab, Pakistan in order to evaluate those vital metals involved in human health implications. These plant species were:Dodonaea viscosa, Withania somnifera, Solanum nigrum, Calotropis gigantea, Mentha spicata, Paganum hermala, Cannabis sativa, Adhatoda...

Author(s): Zafar Iqbal Khan, Kafeel Ahmad, Mian Jahan Zaib Rasheed, Rab Nawaz, Muhammad Ayub, Ameer Fawad Zahoor, Anbreen Anjum, Muhmmad Yousaf, Zahoor Ul Hassan Dogar, Khalil Ur Rahman, Abdul Rauf, Muhammad Khalid Mukhtar, Syed Ali Hassan Naqvi, Muneeba Shaheen, Asia Fardous, Sumaira Gondal, Shazia Naheed, Sajjad Ahmad, Ghulam Hussain, Muhammad Sher,  Fahim Arshad, Kalsoom Ghulam Ali and Bushra Parveen

June 2013

Ethnobotanical survey on plants of veterinary importance around Al-Riyadh (Saudi Arabia)

Ethnobotanical survey was conducted on ethno-veterinary medicinal plants used by people living in Al-Riyadh, Saudi Arabia.The aim of the study was to prepare an inventory of medicinal plants used for the curing of different livestock ailments. Ethno-veterinary knowledge of local people was collected through questionnaire and interviews during field trips. Fifty-two plant species were identified as being used for...

Author(s): Hassan Sher and Ali Aldosari

June 2013

Potential of soil fungi to produce penicillin V acylase and its optimization conditions

Fifty fungal isolates representing 31 species, related to 8 genera, were isolated from soil and screened for their abilities to produce endo- and exocellular penicillin V acylase enzymes. For endocellular enzyme, eleven isolates (represent 22% of total isolates) exhibited high enzyme activity and 9 isolates (18%) had moderate ability. However, twenty isolates (40%) were low producers and ten isolates (20%) had no...

Author(s): A. M. Moharram, A. Saleem, R. M. Abdel-Aziz and N. Fathy

June 2013

Spectrophotometric study of the anti-caseinolytic activity of root extracts of Teclea nobilis and Vepris zambesiaca on Bitis arietans venom

The study focused on the inhibition of the caseinolytic activity of Bitis arietans venom by aqueous methanol crude root extracts of Teclea nobilis and Vepris zambesiaca. Snake venom samples were collected from Snake World near Harare, and the medicinal plants were obtained from Mash Central Province, Zimbabwe. Data on the kinetics of the digestion of casein by the B. arietans venom and...

Author(s): Tigere Chayamiti, Eddie Mwenje and Courtie Mahamadi