African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Table of Content: 8 November, 2012; 6(41)

November 2012

Antihyperglycemic, antidyslipidemic and antioxidant activity of Rhus coriaria in STZ-induced type 2 diabetic rats

The potential role of methanolic extract of Rhus coriaria L. on hyperglycemia, dyslipidemia and lipid peroxidation (LPO) was studied in type 2 diabetic rats. Type 2 diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ, 100 mg/kg) to 2 days old rat pups. R. coriaria (200 and 400 mg/kg) was administered orally once a day for 5 weeks after the animals were confirmed diabetic...

Author(s): Tarique Anwer, Manju Sharma, K. K. Pillai, Gyas Khan, and Mohammad M. Safhi

November 2012

Hepatoprotective activity of Trapa acornis shell extracts against CCl4-induced liver injury in rats

Trapa acornis (TA) pulp is one of the most popular vegetables and fruits with unique taste in China. Our previous study showed that T. acornis shell (TAS) had strong antioxidant activityin vitro. Polyphenols and flavonoids have contributed to antioxidant activity; and hepatoprotective activity also has relationship with antioxidant activity. Nevertheless, there have been no reports on total phenolic...

Author(s): Wen-yi Kang, Yuan-yuan Li, Xue-zhu Gu and Xuan Huang

November 2012

Preparation of the composite material of bioactive glass and chitosan for bone repair

The aim of this work was to develop a bioactive glass/chitosan (BG/CS) composite material for bone repair. Hydrochloric solution was properly mixed. Bioactive glass was added to make CS/BG mixed liquor. The microstructure and composition were observed and analyzed. The third-generation rabbit mesenchymal stem cells were inoculated into the stent. The adhesion of the stent was detected,...

Author(s): Shao-bo ZHU, Chen SUN, Ai-xi YU, Tao ZHANG, Qi-lin MEI and Xing HU

  • Article Number: FF028D330200

November 2012

Effect of chymase inhibitors on dimethylnitrosamine-induced rat liver fibrosis and on chymase and collagen I expression

Chymase converts angiotensin (Ang) I to Ang II, which may promote the development of liver fibrosis. In this study, a chymase inhibitor TY-51469 attenuated dimethylnitrosamine (DMN)-induced liver fibrosis was examined. A total of 44 rats were randomly divided into three groups: The model group, the control group, and the chymase inhibitor treatment (Chy-I) group. The rats were given intraperitoneal injections of 1% DMN...

Author(s): Mingshi Yin, Shilan Jin and Hesong Cui

November 2012

The effects of the edible bird’s nest on sexual function of male castrated rats

In this study, the effects of edible bird’s nest on sexual function of male castrated rats were investigated for the first time. The testosterone (T), luteinizing hormone (LH) and estradiol (E2) levels, the penis and prostate and seminal vesicle indexes, and the protein expression of endothelial nitric oxide synthase (eNOS) were estimated. The prostate and seminal vesicle index and the expression of eNOS increased...

Author(s): Fu-cui Ma, Dai-cheng Liu and Mei-xue Dai

November 2012

Effect of vitamin D supplementation on cold restraint induced oxidative stress in rats

Free radicals are electrically charged molecules that are produced during the course of normal metabolism. They spontaneously attack lipids, proteins, nucleic acids and other biologically important molecules. Polyunsaturated lipids are particularly sensitive to their attack. Free radicals and oxidative stress have been reported to be involved in tissue injury associated with a number of diseases. The present study was...

Author(s): Khaled Abd-Elsater Elewa, Misbahuddin Mohd Rafeeq and Mohammad Mohiuddin

November 2012

Evaluation of antitumour action of Ganoderma lucidum extract in hepatocarcinoma mice

The present study shows the protective effects of the Ganoderma lucidum aqueous crude extract (GLE) against mice liver cancer. The mice were randomized into four groups, namely, controls and tumor bearers that were G. lucidum extract- treated or untreated. Tumor bearers were inoculated intraperitoneally (ip) with 108 Yoshida AH-130 ascites hepatoma cells, whereas the controls received saline alone....

Author(s): Xiuying Wu, Honggeng Guan, Jianzhong Li, Jianzheng Guo and Baoyuan Hou

November 2012

Antioxidant and a-glucosidase inhibitory activity of Adina rubella Hance in vitro

Antioxidant activity of extracts from Adina rubella Hance (AR) was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 2,2′-azino-bis (3-ethylbenzothiazoline)-6-sulphonic acid diamonium salt (ABTS) radical scavenge and ferric reducing antioxidant power assay (FRAP) with BHT (2,6-Di-tert-butyl-4-methyiphenol) as positive control, and α-glucosidase inhibitory activity assay of AR...

Author(s): Yibing Zhang, Zhenhua Yin, Xuezhu Gu and Wenyi Kang

November 2012

Antimicrobial effects of yarrow (Achillea millefolium) essential oils against Staphylococcus species

Staphylococcus aureus, a gram positive, non-motile, catalase and coagulase positive, facultative anaerobe coccus is a common type of bacteria that normally lives on the skin and nasal passages of healthy people. The genus Achillea (Asteraceae) was named after the mythological Greek warrior Achilles who used Achillea species for healing wounded-soldiers during the Trojan war. The genus Achillea...

Author(s): Eilyad Issabeagloo,  Mohammad taghizadieh, Babak Abri

November 2012

Intervention study on Saccharomyces boulardii with proton pump inhibitor (PPI)-based triple therapy for Helicobacter pylori related peptic ulcer

The study was undertaken to investigate the efficacy and safety of Saccharomyces boulardiicombined with proton pump inhibitor (PPI)-based triple therapy for Helicobacter pylori related peptic ulcer. One hundred patients with H. pylori infection were randomized in two groups: intervention and control group. Both groups were treated with the standard triple eradication therapy...

Author(s): Yi Chu, Hongyi Zhu, Yuqian Zhou, Liang Lv and Jirong Huo