November 2016

Phenytoin: Is it genotoxic in isolated cultured human lymphocytes without metabolic activation by S9?

There are many conflicting reports around the phenytoin (PHT)-induced genotoxic effect especially in the in-vitro studies. PHT was claimed to cause genotoxic effect by the oxidative stress of its metabolic intermediates. However, by reviewing the distribution and activity of the enzymes responsible for PHT metabolism, we found that PHT is rarely metabolized by human lymphocytes. So that, we will use isolated cultured...

Author(s): Mahmoud A. Naga, Ahmad Shata and Hany Ahmed El kattawy

November 2016

Biochemical and histological evaluation of benzo[a]pyrene induced nephrotoxicity and therapeutic potentials of Combretum zenkeri leaf extract

This study determined the therapeutic effect of ethanol leaf extract of Combretum zenkeri on kidney function of rats exposed to benzo[a]pyrene. Male Wistar albino rats were  treated with ethanol leaf extract of C. zenkeri (400 mg/kg) in the presence or absence of BaP (200 mg/kg) for four weeks. The blood obtained at the end of the treatment was processed into serum and used for biochemical analyses and kidney...

Author(s): Ogbonna C. U., Ujowundu C. O., Okwu G. N., Emejulu A. A., Alisi C. S. and Igwe K. O.