June 2022

Formulation and evaluation of gastro-retentive floating tablets of griseofulvin

About 50% of an oral dose of griseofulvin passes through the gastro-intestinal tract unabsorbed and is excreted in faeces. Short residence time of the low soluble griseofulvin, in stomach and small intestine, limits its dissolution.  Griseofulvin is highly soluble in acidic pH, and so a gastro-retentive floating matrix system was developed to control dissolution rate and thereby enhance solubility to develop an...

Author(s): Jonathan Tinotenda Chanyandura, Madan Sai Poka, Patrick Hulisani Demana and Musa Autamashih  

June 2022

In vivo antiplasmodial activity of an aqueous extract of leafy stems of Ipomoea pes-caprea (L.) R.Br. in Swiss mice infected with Plasmodium berghei

The study aimed to evaluate the in vivo antiplasmodial activity of an aqueous extract of aerial parts of Ipomoea pes-caprea in mice infected with Plasmodium berghei. Extracts of Ipomoea pes-caprea were obtained from the decoction of the dried leafy stem of the plant. The extracts obtained were used for the evaluation of the antiplasmodial activity which was done according to two methods: the Rane test was used to...

Author(s): Eric Gbongué TIA, Thierry-Lenoir Ayoman DJADJI, Landry Sylvain KOUAKOU, karim TUO, Etienne Kouakou EFFO, Adebo Yacouba ADEHOUNI, Nounaféri Awa Gniènèfèrètien SILUE, Axelle Edith Ahou KOUADIO, Geneviève N’GUESSAN-IRIE and  Gisèle N’doua KOUAKOU-SIRANSY