June 2025

Phenytoin dosing practices for traumatic brain injury seizure prophylaxis in the absence of the availability of therapeutic drug monitoring in Uganda: A chart review study

Phenytoin is commonly used for seizure prophylaxis in patients with traumatic brain injury at Mulago National Referral Hospital in Kampala, Uganda. However, phenytoin therapeutic drug monitoring is not available in this low-resource setting. Anecdotes of breakthrough seizures in patients on phenytoin from healthcare providers at this institution prompted this quality improvement study. This study aimed to characterize...

Author(s): KarenBeth H. Bohan, Winnie Nambatya, Melanie R. Nicol, Prosperity Eneh, Su Phyu and Richard Odoi Adome