March 2008

Effect of Grewia gum on the mechanical properties of paracetamol tablet formulations

Grewia gum has been evaluated as a binder in paracetamol tablet formulations. Compressional properties of the formulations were analyzed using density measurements and the compression equations of Heckel and Kawakita as assessment parameters. Formulations containing Grewia gum as a binder show a slower onset and lower amount of plastic deformation than those containing PVP. The Db values for formulations...

Author(s): Emeje Martins, Isimi Christiana and Kunle Olobayo

March 2008

Antimicrobial activity of leaf extracts of Senna obtusifolia (L)

Antimicrobial properties of leaf extracts of Senna obtusifolia (L) were investigated against both clinical and laboratory isolates of both bacteria and fungi using the disc diffusion method. Acetone extracts (12 mm zone diameter of inhibition, MIC 200 μg/mL and MBC 300 μg/mL) demonstrated the highest activity, followed by dichloromethane (8 mm zone diameter of inhibition, MIC 300 μg/mL and MBC 400...

Author(s): Doughari, J. H, El-mahmood, A. M. and Tyoyina, I