African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: October 2008; 2(8)

October 2008

Effect of viscosity grades of ethylcellulose on the sustained release properties of indomethacin from its tablets matrix

The objective of the present study was to estimate the influence of ethyl cellulose (EC) with different viscosity grades on in vitro drug release from EC matrix tablets containing Indomethacin.  Four viscosity grades of EC (7, 10, 50 and 100 cp) were studied. The 90 - 125/µm particle size fraction was collected by manual dry sieving and the compression force was varied to produce...

Author(s): Amri Ahmed and Sfar Souad

  • Article Number: 76A6D7832623

October 2008

Determination of prednisolone, dexamethasone and hydrocortisone in pharmaceutical formulations and biological fluid samples by voltammetric techniques using b-cyclodextrin modified carbon paste electrode

A simple, sensitive and accurate voltammetric studies on prednisolone (PE), dexamethasone (DE) and hydrocortisone (HC) were carried out by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at bare carbon paste electrode (CPE) and β-cyclodextrin modified carbon paste electrode (CDMCPE) in Britton-Robinson (BR) buffer solution. PE, DE and HC show marked enhancement of peak currents at CDMCPE when...

Author(s): K. Balaji, G. V. Raghunadha Reddy, T. Madhusudana Reddy and S. Jayarama Reddy

  • Article Number: 4F8C5D732636

October 2008

Evaluation of antimicrobial potentials of stem bark extracts of Cochlospermum planchoni

Antimicrobial activity of root extracts of Cochlospermum planchoni against some pathogenic bacteria and fungi were investigated using the filter paper disc diffusion method. Phytochemical studies revealed the presence saponins, tannins, glycosides and aikaloid as phytochemicals. Methanol extracts (40 mg/ml) exhibited the highest activity (16 - 30 mm zone diameter of inhibition, MIC and MBC values 2.5 - 22.5...

Author(s): Doughari, J. H., El-Mahmood, A. M. and Phillip, B.

  • Article Number: 5E9FCEC32650

October 2008

Antidiabetic activity of hydro-ethanolic extracts of Nymphaea Stellata flowers in normal and alloxan induced diabetic rats

The antidiabetic effect of hydro-ethanolic extract (HEE) of Nymphaea stellata Willd flower was investigated in normal and alloxan-induced diabetic rats. In the present study, the animals were divided in to normal control, diabetic control, diabetic treated and control treated group (n = 6). Effect of oral administration of HEE (300 mg/kg) for 30 days on the level of blood glucose, glycosylated...

Author(s): K. Rajagopal and K. Sasikala

  • Article Number: 91E566032656

October 2008

Accelerated stability testing of celecoxib nanoemulsion containing Cremophor-EL

Celecoxib (CXB), a selective cyclooxygenase-2 inhibitor has been recommended for the treatment of arthritis and osteoarthritis upon oral administration. However, long term oral administration of celecoxib cause serious gastrointestinal adverse effects. Therefore the aim of the present study was to enhance CXB’s physical and chemical stability using nanoemulsion formulation in order to eliminate gastrointestinal...

Author(s): Faiyaz Shakeel, Sanjula Baboota, Alka Ahuja, Javed Ali and Sheikh Shafiq

  • Article Number: 08DC05732665