African Journal of
Plant Science

  • Abbreviation: Afr. J. Plant Sci.
  • Language: English
  • ISSN: 1996-0824
  • DOI: 10.5897/AJPS
  • Start Year: 2007
  • Published Articles: 686

Full Length Research Paper

Evaluation of anthelmintic activity of the stem bark extract and chemical constituents of Bridelia ferruginae (Benth) Euphorbiaceae

Lasisi A. A.1* and Kareem S. O.2
1Drug Research Unit, Department of Chemistry, University of Agriculture, Abeokuta, Ogun State, Nigeria. 2Department of Microbiology, University of Agriculture, Abeokuta, Ogun State, Nigeria.
Email: [email protected]

  • Article Number - 5F21DB110050
  • Vol.5(8), pp. 469-474, August 2011
  •  Accepted: 15 June 2011
  •  Published: 31 August 2011

Abstract

Anthelmintic properties of the stem bark extract and compounds isolated from Bridelia ferruginae were investigated. In relation to the traditional use of B. ferruginae against gastro-intestinal infections, bioactivity-guided fractionations of the CHCl3- and CH2Cl2-soluble fractions of the 80% MeOH extract from the stem barks of B. ferruginae yielded two known triterpenoids: betuline (1), glucoside of betulinic acid (2) and other two known flavonoids: quercetin (3) and kaempferol (4). Structures of compounds 1 to 4 were elucidated by spectroscopic studies and comparison with related compounds in literature. The time of paralysis and death of the parasitic worms: Fasciola gigantical(liver fluke), Taenia solium (tape worm) and Pheritima posthuma (earthworm, Annelid) were determined at 25, 50, 80 and 100 mg/ml. The stem barks extract of Bferruginaeand isolated compounds demonstrated concentration-dependent anthelmintic potencies against parasitic worms assayed. Structural-activity relationship is explained.

 

Key words: Bridelia ferruginae, anthelmintic activity, betulinic acid, betuline, quercetin, kaempferol.

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