Biotechnology and Molecular Biology Reviews

  • Abbreviation: Biotechnol. Mol. Biol. Rev.
  • Language: English
  • ISSN: 1538-2273
  • DOI: 10.5897/BMBR
  • Start Year: 2006
  • Published Articles: 101

Review

Key aspects of the mesenchymal stem cells (MSCs) in tissue engineering for in vitro skeletal muscle regeneration

Biswadeep Chaudhuri and Krishna Pramanik*
Department of Biotechnology and Medical Engineering, National Institute of Technology – Rourkela - 769008, India.
Email: [email protected]

  •  Accepted: 21 February 2012
  •  Published: 31 March 2012

Abstract

Tissue engineering, directly associated with Biotechnology and Biomedical Sciences, is an emerging field of research and development. The main issue of tissue engineering is to precisely and safely regenerate or reconstruct injured tissues of skeletal muscle, bone, teeth, neural, cardiac, cartilage etc. One of the primary requirements for tissue engineering development is a constant source of supplementary stem cells which have the ability to be differentiated into various tissue types such as condroblast, osteoblast or myoblast cells. In modern tissue engineering, mesenchymal stem cells (MSCs) take the most important part forin vitro growth or regeneration of the required tissues. Selective growth factors are also needed to optimize the growth process. In the preset review, an attempt has been made to focus on the crucial beneficial issues of mesenchymal stem cells for the skeletal muscle regeneration and repair. Though the detailed processes on how dystrophic muscles are replaced by fibrotic tissues inside living organs is still not very clearly understood, we have briefly discussed the overall ideas and future prospects of skeletal muscle regeneration (in vitro) using MSCs on 3D scaffold with optimum experimental conditions (use of various medias, growth factors etc.).

 

Key words: Mesenchymal stem cell, skeletal muscle, tissue engineering, tissue regeneration, growth factors, medical implant, biomaterials.