Abstract

The drug discovery is a very much time consuming as well as costly procedure. The Mass Spectrometry (MS) technology offers the aptitude for characterization, identification, as well as quantification of a target entity in a complex matrix and has settled into a leading analytical tool in the field of medicinal chemistry and drug discovery. However, by using specific MS-based techniques including personalized sample design, coupling to the gas and liquid chromatography and various ionization techniques, both qualitative as well as quantitative analysis of small molecular drug particles can be obtained. The current review describes MS strategies which are used to enhance and accelerate drug identification besides degradation linked impurities in active pharmaceutical ingredients (API) or articulated products. The level of protein expression is often termed as proteomics research. With use of MS technology, we can learn more reliable as well as dynamic ways of protein analysis.

Key words: MS, drug discovery, active pharmaceutical ingredients (API), spectroscopy.