Division of the ancestral prokaryotic genome into two circular double-stranded deoxyribonucleic acid (DNA) molecules by genetic recombination, is a basis for the future separate evolution of the nuclear and mitochondrial gene compartment. This suggests monophyletic origin of both mitochondrion and nucleus. Presumed organism which genome undergoes genetic recombination has to be searched among an aerobic, oxygen non-producing archaeon with no rigid cell wall, but a plasma membrane, probably an crenarchaeota containing functional bacteriochlorophyll a synthase gene and histones. In this proposal, origin of eukaryotes occur by a three-steps. First, replication fork pauses and collapses generating a breakage in the genome of archaeal ancestor of eukaryotes. Second, the double-strand break can be repaired intergenomically by complementary strands invasion. Third, this duplicated genome can be fissioned into two compartments by reciprocal genetic recombination. Scenario is accomplished by aberrant fission of the inner membane surrounding separately those two compartments.
Key words: Origin of nucleus, origin of mitochondrion.
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