HIV infection and AIDS are serious public health issues globally. Nigeria has one of the highest rates of new HIV infections in Sub-Saharan Africa and the world's second highest HIV burden. Patients’ continuity of treatment (CoT) is critical towards achieving HIV control. This study aims to explore individual and associated factors of HIV treatment continuity among PLHIV in Nigeria. For this review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and Cochrane guidelines was adapted. Findings from the studies showed that individual patient’s demography such as (89%), socio economical (89%), geographical (50%), behavioural (33%) and clinical factors (44%) have significant association with patient continuity of treatment. Furthermore, 61% of included study had cross cutting of factors associated with continuity of treatment. 89% (n=16), individual factors, 89% (n=16) socio economic factors, 50% (n=9) geographical/environmental settings, 33% (n=6) behavioural factors, and 44% (n=8) clinical factors. Because more male has demonstrated significant level on interruption in treatment compared to the female, the study recommends that a deliberate effort to finding men and ensuring men are on treatment should be implemented.

Keywords: Antiretroviral therapy (ART), Continuity of treatment (CoT), Retention, Interruption in treatment (IIT), PLHIV, PRISMA.