International Journal of
Genetics and Molecular Biology

  • Abbreviation: Int. J. Genet. Mol. Biol.
  • Language: English
  • ISSN: 2006-9863
  • DOI: 10.5897/IJGMB
  • Start Year: 2009
  • Published Articles: 131

Full Length Research Paper

Colorectal cancer, TGF-β signaling and SMADs

A. Syed Sameer1,2, Safiya Abdullah1, Mujeeb Z. Banday3, Nidda Syeed1 and Mushtaq A. Siddiqi1*
  1Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India 190011. 2Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India. 190011. 3Department of Biotechnology, University of Kashmir, Hazratbal, Srinagar, Kashmir, India 190011.
Email: [email protected]

  •  Accepted: 31 March 2010
  •  Published: 30 June 2010



Colorectal cancer (CRC) being the commonest cancer, is the major cause of mortality and morbidity worldwide. TGF-β pathway is one of the important pathways that play a prominent role in cell proliferation, differentiation, migration and apoptosis. Smad dependent TGF-β signaling cascade is responsible for the regulation and expression of almost 500 odd genes, which in turn play important role in the proper development of intestinal mucosa. Here in this review we have discussed the overall machinery of theTGF-β pathway and the advances in the mutational research on SMAD4 gene in cancers with special look on our own research in CRC cases of Kashmiri population.


Key words: Colorectal cancer, Kashmir, SMADs, mutations, PCR-SSCP.