International Journal of
Genetics and Molecular Biology

  • Abbreviation: Int. J. Genet. Mol. Biol.
  • Language: English
  • ISSN: 2006-9863
  • DOI: 10.5897/IJGMB
  • Start Year: 2009
  • Published Articles: 131

Clinical features in a pediatric population due to chromosome deletions at a third level pediatric Mexican hospital in 19 years period of time: Five case reports

  Aparicio-Rodríguez J. M.1,5*, Hurtado-Hernández M. D. L.2, Barrientos-Pérez M.3, Zamudio-Meneses R.4, Palma-Guzmán M.5, Chavez-Ozeki H.5 and Chatelain-Mercado S.6
  1Department of Genetics, Hospital Para El Niño Poblano Bolv Del Nino Poblano 5307, Col Concepcion La Cruz CP, 72197 Puebla, Mexico. 2Department of Cytogenetics, Hospital Para El Niño Poblano Bolv Del Nino Poblano 5307, Col Concepcion La Cruz CP, 72197 Puebla, Mexico. 3Department of Endocrinology, Hospital Para El Niño Poblano Bolv Del Nino Poblano 5307, Col Concepcion La Cruz CP, 72197 Puebla, Mexico. 4Department of Cardiology, Hospital Para El Niño Poblano Bolv Del Nino Poblano 5307, Col Concepcion La Cruz CP, 72197 Puebla, Mexico. 5Department of Estomatology, Benemérita Universidad Autónoma de Puebla México. 6Department of Biotechnology, Universidad Autónoma Metropolitana, Mexico.
Email: [email protected]

  •  Accepted: 16 January 2011
  •  Published: 28 February 2013

Abstract

 

Chromosome aberrations are considered as alterations in the chromosome number or structure. They are mainly due to gametogenesis inborn error (meiosis) or occur during the zygote first cellular divisions where DNA repair processes are deficient.  Two Wolf Syndrome patients and two criduchat patients or patients with deletion of the short arm of chromosome 4 and 5, respectively, and deletion of chromosome 9 in one patient, were observed among 4617 karyotype studies performed from 1992 to 2011, at the Hospital Para El Niño Poblano (Pediatric Hospital) in Mexico. These chromosome structural alterations or deletions at chromosomes 4, 5 and 9, observed among five patients from three different families were chosen to analyze their clinical characteristics, medical or surgical treatments and their medical evolution according to the genetic disease.

 

Key words: Chromosome, deletion, chromosome aberration, structural changes, karyotype.