International Journal of
Genetics and Molecular Biology

  • Abbreviation: Int. J. Genet. Mol. Biol.
  • Language: English
  • ISSN: 2006-9863
  • DOI: 10.5897/IJGMB
  • Start Year: 2009
  • Published Articles: 131


The molecular aspects of oral mucocutaneous diseases: A review

S. Sangeetha* and Dhayanand John Victor
Department of Periodontics, SRM Dental College, Chennai, India
Email: [email protected]

  •  Accepted: 19 October 2011
  •  Published: 30 November 2011



Most of the mucocutaneous diseases are confined to the stratified squamous epithelium and thus may involve skin, oral and other mucosae like the nasal, ocular, genital mucosa. Some patients present with oral lesions only whereas in others there may be involvement of skin and other mucous membranes. An understanding of the basic molecular aspects of these disorders is essential for proper diagnosis. Once a definitive diagnosis is determined, treatment is focused upon the alleviation of clinical signs and symptoms, referral for consultation with other specialists to assess the extent of the disease process, and the prevention of recurrence.


Key words: Mucocutaneous disease, desquamative gingivitis, vesiculobullous disorder, pemphigus vulgaris, pemphigoid.


Abbreviations: Dsg, Desmogleins; BP, bullous pemphigoid; CP, cicatricial pemphigoid;HLA, human leukocyte antigen; ELISA, enzyme linked immunosorbent assay; PV,pemphigus vulgaris; MHC, major histocompatibility complex; TNF, tumour necrosis factor;IFN-γ, Interferon-gamma; LABD, linear IgA bullous dermatosis; HAEM, herpes associated erythema multiforme; ICAM-1, inter-cellular adhesion molecule 1; VCAM-1, vascular cell adhesion molecule-1; ELAM- 1, Endothelial Leukocyte Adhesion Molecule 1; RANTES,regulated upon activation, normal T-cell expressed, and secreted; IP-10, interferon gamma-induced protein 10; NF-KB, nuclear factor kappa B.