International Journal of
Genetics and Molecular Biology

  • Abbreviation: Int. J. Genet. Mol. Biol.
  • Language: English
  • ISSN: 2006-9863
  • DOI: 10.5897/IJGMB
  • Start Year: 2009
  • Published Articles: 139

Article in Press

Mapping of fourteen high-risk human papillomavirus genotypes by molecular detection in sexually active women in the West African sub-region

Théodora Mahoukèdè Zohoncon, Wendkuuni Florencia Djigma, Abdoul Karim Ouattara, Ina M.A Traore, R. Alice Ouedraogo, Esther M.A Traoré, Prosper Bado, T. Clarisse Ouedraogo, Birama Diarra, Maimouna Ilboudo, Callinice D. Capo-chichi, Dorcas Obiri-Yeboah, Simplice Damintoti Karou, Mady Nayama, Apollinaire Horo, Kouame Privat Kouakou, Moutawakilou Gomina, Souleymane Ouattara, Ambaliou Sanni, Akpona Simon, Charlemagne Ouedraogo, Jacques Simpore

  •  Received: 26 December 2019
  •  Accepted: 29 January 2020
The aim of this study was to determine the distribution of high-risk human papillomavirus genotypes (HR-HPV) in women from general population of five West African countries.This was a cross-sectional descriptive study, involving 2133 women from nine cities of five West African countries: Benin, Burkina Faso, Côte d'Ivoire, Niger and Togo. Women were screened for precancerous cervical lesions and HR-HPV infection. The detection of HR-HPV was done by a multiplex real-time PCR on extracted viral DNA. The average age of the women in this study was 35.06 ± 10.00 years with a range of 15 to 65 years. The overall prevalence of high-risk HPV infection among general population sample of women in five West African countries was 33.61% (717/2133). The prevalence of dysplasia was 8.81%. In decreasing order of frequency, the genotypes found were: HPV 52 followed by HPV 31, 59, 51, 66, 45, 68, 56, 56, 58, 35, 39, 18, 33 and 16. The prevalence of HPV16/18 (bivalent vaccine types) was 7.02%. This study reveals a high prevalence of HPV 52 in West Africa. The extent and diversity of HR-HPV genotypes in these West African countries deserve special attention for prevention.

Keywords: High-risk HPV, real time PCR, genotypes, women, epidemiology, West Africa.