International Journal of
Genetics and Molecular Biology

  • Abbreviation: Int. J. Genet. Mol. Biol.
  • Language: English
  • ISSN: 2006-9863
  • DOI: 10.5897/IJGMB
  • Start Year: 2009
  • Published Articles: 131

Full Length Research Paper

Association of the extracellular superoxide dismutase Ala40Thr polymorphism with type 2 diabetes mellitus and its complications in Lebanese population

Nahed Saad
  • Nahed Saad
  • Department of Biological and Environmental Science, Faculty of Science, Beirut Arab University, Lebanon.
  • Google Scholar
Mohamed E. Moustafa
  • Mohamed E. Moustafa
  • Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria 21511, Egypt.
  • Google Scholar
Hala A. Chamieh*
  • Hala A. Chamieh*
  • Department of Biology, Faculty of Science, Lebanese University, Lebanon.
  • Google Scholar


  •  Received: 13 May 2015
  •  Accepted: 22 December 2015
  •  Published: 31 January 2016

References

Adachi T, Inoue M, Hara H, Maehata E, Suzuki S (2004). Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients. J. Endocrinol. 181:413-417.
crossref

 

Carlsson LM, Marklund SL, Edlund T (1996). The rat extracellular superoxide dismutase dimer is converted to a tetramer by the exchange of a single amino acid. Proc. Nat. Acad. Sci. USA 93:5219-5222.
crossref

 

Chistyakov DA, Savost'anov KV, Zotova EV, Nosikov VV (2001). Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus. BMC Med. Genet. 2:4.
crossref

 

Dong X, Li D, Liu H, Zhao Y (2014). SOD3 and eNOS genotypes are associated with SOD activity and NO. Exp. Ther. Med. 8:328-334.
crossref

 

Fattman CL, Schaefer LM, Oury TD (2003). Extracellular superoxide dismutase in biology and medicine. Free Radic. Biol. Med. 35:236-256.
crossref

 

Folz RJ, Crapo JD (1994). Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene. Genomics 22:162-171.
crossref

 

Fukai T, Ushio-Fukai M (2011). Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid. Redox Signal. 15:1583-1606.
crossref

 

Jung O, Marklund SL, Geiger H, Pedrazzini T, Busse R, Brandes RP (2003). Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice. Circ. Res. 93:622-629.
crossref

 

Naganuma T, Nakayama T, Sato N, Fu Z, Soma M, Aoi N, Usami R (2008). A haplotype-based case-control study examining human extracellular superoxide dismutase gene and essential hypertension. Hypertens. Res. 31:1533-1540.
crossref

 

Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K (2014). Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res. Int. 2014:761264.
crossref

 

Sentman ML, Jonsson LM, Marklund SL (1999). Enhanced alloxan-induced beta-cell damage and delayed recovery from hyperglycemia in mice lacking extracellular-superoxide dismutase. Free Radic. Biol. Med. 27:790-796.
crossref

 

Stenlund P, Andersson D, Tibell LA (1997). Subunit interaction in extracellular superoxide dismutase: effects of mutations in the N-terminal domain. Protein Sci. 6:2350-2358.
crossref

 

Tamai M, Furuta H, Kawashima H, Doi A, Hamanishi T, Shimomura H, Sakagashira S, Nishi M, Sasaki H, Sanke T, Nanjo K (2006). Extracellular superoxide dismutase gene polymorphism is associated with insulin resistance and the susceptibility to type 2 diabetes. Diabetes Res. Clin. Pract. 71:140-145.
crossref

 

Tan RJ, Zhou D, Xiao L, Zhou L, Li Y, Bastacky SI, Oury TD, Liu Y (2015). Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. J. Am. Soc. Nephrol. 26:2447-2459.
crossref

 

Ukkola O, Erkkilä PH, Savolainen MJ, Kesäniemi YA (2001). Lack of association between polymorphisms of catalase, copper-zinc superoxide dismutase (SOD), extracellular SOD and endothelial nitric oxide synthase genes and macroangiopathy in patients with type 2 diabetes mellitus. J. Intern. Med. 249:451-459.
crossref

 

Yamada H, Yamada Y, Adachi T, Goto H, Ogasawara N, Futenma A, Kitano M, Miyai H, Fukatsu A, Hirano K, Kakumu S (1997). Polymorphism of extracellular superoxide dismutase (EC-SOD) gene: relation to the mutation responsible for high EC-SOD level in serum. Jpn. J. Hum. Genet. 42:353-356.
crossref

 

Zelko IN, Mariani TJ, Folz RJ (2002). Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic. Biol. Med. 33:337-349.
crossref