International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 528

Full Length Research Paper

Anti-hyperglycaemic, lipid lowering and anti-oxidant properties of [6]-gingerol in db/db mice

Amar Bahadur Singh
  • Amar Bahadur Singh
  • Biochemistry Division, Central Drug Research Institute, Lucknow-226001, India.
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Akanksha
  • Akanksha
  • Medicinal and Process Chemistry Division, CDRI, Lucknow-226001, India.
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Nilendra Singh
  • Nilendra Singh
  • Pharmacology Division CDRI, Lucknow-226001, India.
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Rakesh Maurya
  • Rakesh Maurya
  • Medicinal and Process Chemistry Division, CDRI, Lucknow-226001, India.
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Arvind Kumar Srivastava
  • Arvind Kumar Srivastava
  • Biochemistry Division, Central Drug Research Institute, Lucknow-226001, India.
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  •  Accepted: 03 August 2009
  •  Published: 31 December 2009

Abstract

In the present study, we investigated the blood glucose lowering, lipid lowering and antioxidant effect of [6]-gingerol in type 2 diabetic db/db mice. Treatment of db/db mice with [6]-gingerol (100 mg/kg bw) for 12 days significantly (p<0.05) lowered fasting blood glucose and improved the glucose tolerance in db/db mice. Oral administration of [6]-gingerol also significantly (p < 0.05) decreased plasma triglycerides (TG), total cholesterol (TC), free fatty acid (FFA), low-density lipoprotein cholesterol (LDL-C) and plasma insulin concentration. In addition, [6]-gingerol significantly (p < 0.05) reduces the content of hydrogen peroxide or suppresses the reactive oxygen species (ROS) generation and restores the enzyme activity of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in db/db mice. These findings suggest that [6]-gingerol exhibits a significant potential as an anti-hyperglycaemic, lipid lowering and anti-oxidant agent for the treatment of type 2 diabetes.

Key words: Antihyperglycaemic, antioxidant, antilipidemic, reactive oxygen species, db/db mice, [6]-gingerol..