International Journal of
Nutrition and Metabolism

  • Abbreviation: Int. J. Nutr. Metab.
  • Language: English
  • ISSN: 2141-2332
  • DOI: 10.5897/IJNAM
  • Start Year: 2009
  • Published Articles: 128

Full Length Research Paper

Anti-hyperglycemic effect of cocoyam (Xanthosoma sagittifollium) corm in alloxan-induced diabetic albino rats

Oluyemisi Folake FOLASIRE
  • Oluyemisi Folake FOLASIRE
  • Department of Human Nutrition, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
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Olayinka Ayotunde ORIDUPA
  • Olayinka Ayotunde ORIDUPA
  • Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
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Adedotun Joshua OWOLABI
  • Adedotun Joshua OWOLABI
  • Department of Human Nutrition, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
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Oladejo Thomas ADEPOJU
  • Oladejo Thomas ADEPOJU
  • Department of Human Nutrition, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
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  •  Received: 24 April 2016
  •  Accepted: 11 July 2016
  •  Published: 31 July 2016

References

Adaramoye OA, Lawal SO (2014). Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on the antioxidant, hormonal and spermatogenic indices of diabetic male rats. Andrologia 46(8):878-886.
Crossref

 

Adeyi AO, Idowu BA, Mafiana CF, Oluwalana SA, Ajayi OL, Akinloye OA (2012). Rat model of food-induced non-obese-type 2 diabetes mellitus: comparative pathophysiology and histopathology. Int. J. Physiol. Pathophysiol. Pharmacol. 4(1):51-58.

 
 

Amusa TA, Enete AA, Okon UE (2011). Socioeconomic determinants of cocoyam production among small holder farmers in Ekiti state, Nigeria. Int. J. Agric. Ecol. Rural Dev. 4(2):97-109.

 
 

Arruda SF, Siqueira EMA, Souza EMT (2004). Malanga (Xanthosoma sagittifolium) and Purslane (Portulaca oleracea) leaves reduce oxidative stress in vitamin D-deficient rats. Ann. Nutr. Metab. 48(4):288-295.
Crossref

 
 

Bahmani M, Zargaran A, Rafieian-Kopaei M, Saki K (2014). Ethnobotanical study of medicinal plants used in the management of diabetes mellitus in the Urmia, Northwest Iran. Asian Pac. J. Trop. Med. 7S1:S348-354.

 
 

Bloomgarden ZT (2004). Type 2 Diabetes in the Young: The evolving epidemic. Diabetes Care 27(4):998-1010.
Crossref

 
 

De Almeida JE, Monteiro EB, Raposo HF, Vanzela EC, Amaya-Farfán J (2013). Taioba (Xanthosoma sagittifolium) leaves: Nutrient composition and physiological effects on healthy rats. J Food Sci. 78(12):H1929-934.
Crossref

 
 

Ejike CECC, Uka NKU, Nwachukwu SO (2015). Diabetes and pre-diabetes in adult Nigerians: prevalence, and correlations of blood glucose concentrations with measures of obesity. Afr. J. Biochem. Res. 9(3):55-60.
Crossref

 
 

Ezuruike UF, Prieto JM (2014). The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations. J. Ethnopharmacol. 155(2):857-924.
Crossref

 
 

Faisal M, Hossain AI, Rahman S, Jahan R, Rahmatullah M (2014). A preliminary report on oral glucose tolerance and antinociceptive activity tests conducted with methanol extract of Xanthosoma violaceum aerial parts. BMC Complement. Altern. Med. 14(1):335.
Crossref

 
 

Herbert OCM, Clement J, Idongesit J, Godwin E, Udeme E, Grace E (2011). Evaluation of the hypoglycemic effect of aqueous extract of Phyllanthus amarusin alloxan-induced diabetic albino rats. Int. J Pharm. Biomed. Res. 2:158-160.

 
 

International Diabetic Federation (IDF) (2016). Diabetes in Africa. Report of International Working Group on the Diabetic Foot. Available at: https://www.idf.org/webdata/docs/background_info_AFR.pdf Accessed Date: 20/04/2016.

 
 

Jennings DL (1987). Starch crops. In: CRC Handbook of plant Science in Agriculture. Volume II. Christie BR (Ed.). CRC Press, Inc. Boca Raton, Florida, USA. pp. 137-143.

 
 

Karou SD, Tchacondo T, Djikpo Tchibozo MA, Abdoul-Rahaman S, Anani K, Koudouvo K, Batawila K, Agbonon A, Simpore J, De Souza C (2011). Ethnobotanical study of medicinal plants used in the management of diabetes mellitus and hypertension in the Central Region of Togo. Pharm. Biol. 49(12):1286-1297.
Crossref

 
 

Kikumoto Y, Sugiyama H, Inoue T, Morinaga H, Takiue K, Kitagawa M, Fukuoka N, Saeki M, Maeshima Y, Wang DH, Ogino K, Masuoka N, Makino H (2010). Sensitization to alloxan-induced diabetes and pancreatic cell apoptosis in acatalasemic mice. Biochim. Biophys. Acta 1802(2):240-246.
Crossref

 
 

Lodovicia M, Giovannellia L, Pitozzia V, Bigaglia E, Bardinib G, Rotellab CM (2008). Oxidative DNA damage and plasma antioxidant capacity in type 2 diabetic patients with good and poor glycaemic control. Mutat. Res. 638(1-2):98-102.
Crossref

 
 

Maritim AC, Sanders RA, Watkins JB (2003). Diabetes, oxidative stress, and antioxidants: a review. J. Biochem. Mol. Toxicol. 17(1):24-38.
Crossref

 
 

Nishanthini A, Mohan VR (2012). Antioxidant activites of Xanthosoma sagittifolium Schott using various in vitro assay models. Asian Pac. J. Trop. Biomed. S1701-S1706.
Crossref

 
 

Onwueme IC, Charles WB (1994). Cultivation of cocoyam. In: Tropical root and tuber crops. Production, perspectives and future prospects. FAO Plant Production and Protection Paper 126, Rome; pp. 139-161.

 
 

Styskal J, van Remmen H, Richardson A, Salmon AB (2012). Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic. Biol. Med. 52(1):46-58.
Crossref

 
 

Szkudelski T (2001). The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50(6):537-546.

 
 

Tiwari BK, Pandey KB, Abidi AB, Rizvi SI (2013). Markers of Oxidative Stress during Diabetes Mellitus. J. Biomark. 2013.
Crossref

 
 

Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V (2001). Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New England J. Med. 344(18):1343-1350.
Crossref

 
 

Ukpong IJ, Abasiekong BO, Etuk BA (2014). Phytochemical screening and mineral elements composition of Xanthosoma sagittifolium inflorescence. Asian J. Plant Sci. Res. 4(6):32-35.

 
 

Lenzen S (2008).Mechanisms of Alloxan- and Streptozotocin-induced diabetes. Diabetologia 51:216-226.
Crossref

 
 

Rohilla A, Ali S (2012). Alloxan Induced Diabetes: Mechanisms and Effects. Int. J. Res. Pharm. Biomed. Sci. 3(2):819-823.