Full Length Research Paper
References
Adeneye AA, Olagunju JO (2009). Protective effect of oral ascorbic acid (Vitamin C) on acetaminophen-induced renal injury in rats. African Journal of Biomedical Research 12(1):55-61. |
|
Adeyina AO, Ogunteye SO, Olatunde OA, Apata DF (2008). Comparative effects of theobromine and cocoa bean shell (CBS) extract on the performance, serum constituent profile and physiological parameters in rabbits. Global Journal of Pure and Applied Science 14(3):253-255. |
|
Adikwu E, Deo O (2013). Hepatoprotective Effect of Vitamin C (Ascorbic Acid). Pharmacology and Pharmacy 4:84-92. |
|
Akpanyung EO, Bassey UE, Udofia EE, Effiong GS (2018a). Effect of ethanol leaf extract of Vernonia amygdalina on some indices of liver, kidney function and lipid profile in theobromine intoxicated male albino Wistar rats. Journal of Food and Nutrition Sciences 6(4):106-114. |
|
Akpanyung EO, Bassey UE, Usoh IF, Iba IU (2015). Effect of combined administration of artequin® and pefloxacin on some indices of liver and renal functions of male albino Wistar rats. Pharmacologyonline 3:84-90. |
|
Akpanyung EO, Nwaokonko DU, Ekong MB and Ekpo MM (2018b). Evaluation of the protective effect of Moringa oleifera leaf extract against aluminium induced liver damage in male albino Wistar rats. International Journal of Sciences 7(2):20-30. |
|
Aneja M, Gianfagna T (2001). Induction and accumulation of caffeine in young, actively growing leaves of cocoa (Theobroma cacao L.) by wounding or infection with Crinipellis perniciosa. Physiological and Molecular Plant Pathology 59:13-16. |
|
Bancroft JD, Gamble M (2002). Theory and Practice of Histological Techniques. 5th ed. Churchill Livingstone, London. |
|
Barter P, Goto AM, LaRosa JC, Maoni J, Szarek M, Grundy SM, Fruchart J (2007). HDL cholesterol, very low levels of LDL cholesterol and Cardiovascular Events. New England Journal of Medicine 357:1301-1310. |
|
Campbell I (2006). Liver: metabolic functions. Anaesthesia and Intensive Care Medicine 7(2):51-54. |
|
Craig WJ, Nguyen TT (1984). Caffeine and theobromine levels in cocoa and cocoa products. Journal of Food Science 49(1):302-303. |
|
Dayuan L, Mehta JL (2005). Oxidized LDL: a critical factor in atherogenesis. Cardiovascular Research 68:353-354. |
|
Esteva-Font C, Castan JB, Fernandez-Llama P (2012). Molecular biology of water and salt regulation in the kidney. Cellular and Molecular Life Sciences 69(5):683-695. |
|
Eteng MU, Ebong PE, Ettarh RR, Umoh IB (1998). Aminotransferase activity in serum, liver and heart tissue of rats exposed to theobromine. Indian Journal of Pharmacology 30(5):339-342. |
|
Friedewald WT, Levy RI, Fredrickson DS (1972). Estimation of the Concentration of LDL cholesterol in plasma, without use of the preparative ultra-centrifuge. Clinical Chemistry 18:499-502. |
|
Gans JH (1984). Comparative toxicities of dietary caffeine and theobromine in the rat. Food and Chemical Toxicology 22:365-369. |
|
Gheshlaghi F (2012). Toxic renal injury at a glance. Journal of Renal Injury Prevention 1(1):15-16. |
|
Howard PA, Meyers DG (1995). Effect of vitamin C on plasma lipids. Annals of Pharmacotherapy 29(11):1129-1136. |
|
Iqbal K, Khan A, Khattak MM (2004). Biological significance of ascorbic acid (Vitamin C) in human health: a review. Pakistan Journal of Nutrition 3(1):5-13. |
|
Jaeschke H, Gores GJ, Cederbraum AI, Hinson JA, Pessayre D, Lemasters JJ (2012). Mechanism of hepatotoxicity. Toxicological Sciences 65:166-176. |
|
Kim SY, Moon A (2012). Drug-induced nephrotoxicity and its biomarker. Biomolecules and Therapeutics 20(3):268-272. |
|
Lamb J, Gulati D, Choudhury H, Chambers R, Poonacha K, Sabharwal P (1997). Theobromine. Environmental Health Perspectives 105(10):353-354. |
|
Markowitz GS, Perazella MA (2005). Drug induced renal failure: a focus on tubulointerstitial disease. Clinica Chimica Acta 351:664-667. |
|
McGill MR (2006). The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI Journal 15:817-828. |
|
National Research Council (1985). Guide for care and use of laboratory animals. Publication of the National Institute of Health. Bethesda, MD. |
|
Niki E (1991). Action of ascorbic acid as a scavenger of active and stable oxygen radicals. American Journal of Clinical Nutrition 54:1119S-1124S. |
|
Niroumand S, Dadgarmoghaddam M, Eghbali B, Abrishami M, Gholoobi A, Taghanaki H, Khajedaluee M (2016). Cardiovascular Disease Risk Factors Profile in Individuals with Diabetes Compared with Non-Diabetic Subjects in North-East of Iran. Iran Red Crescent Medical Journal 18(8):e29382. |
|
Ogedegbe HO (2007). Renal function test: a clinical laboratory perspective. Labmedicine 38(5):295-304. |
|
Pandit A, Sachdeva T, Bafna P (2012). Drug-induced hepatotoxicity: a review. Journal of Applied Pharmaceutical Science 2(5):233–243. |
|
Prakash J, Sen D, Kumar NS, Kumar H, Tripathi LK, Saxena RK (2003). Acute renal failure due to intrinsic renal disease: review of 1122 cases. Renal Failure 25(2):225-233 |
|
Sloop GD, Garber DW (1997). The effect of low-density lipoprotein and High-density lipoprotein on blood viscosity correlates with their association with risk of atherogenesis in humans. Clinical Science 92:473-479. |
|
Smit HJ (2011). Theobromine and the pharmacology of cocoa. Handbook of Experimental pharmacology 2(200):218. |
|
Stadtman E (1991). Ascorbic acid and oxidative inactivation of proteins. American Journal of Clinical Nutrition 54:1125S-1128S. |
|
Steskova A, Morochovicova M, Leskova E (2006). Vitamin C degradation during storage of fortified foods. Journal of food and nutrition research 45(2):55-61. |
|
Strachan ER, Bennett A (1994). Theobromine poisoning in dogs. Veterinary Record 12:284. |
|
Tarka SM (1982). The toxicology of cocoa and methylxanthines. Critical Reviews in Toxicology 9(4):275-312. |
|
Tarladacalisir YT, Kanter M, Uygun M (2008). Protective effect of vitamin C on cisplatin-induced renal damage: a light and electronic microscopic study. Renal Failure 30:1-8. |
|
Trajkovska KT, Topuzovska S (2017). High density lipoprotein metabolism and reverse cholesterol transport: strategies for raising HDL cholesterol. The Anatolian Journal of Cardiology 18:149-154 |
|
William GC (2000). Cocoa and Chocolate. London: Routledge. pp. 10, 31. |
|
Yockey, RD (2011). SPSS Demystified. A Step by Step Guide to Successful Data Analysis. 2nd ed. Prentice Hall. |
Copyright © 2025 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0