International Journal of
Psychology and Counselling

  • Abbreviation: Int. J. Psychol. Couns.
  • Language: English
  • ISSN: 2141-2499
  • DOI: 10.5897/IJPC
  • Start Year: 2009
  • Published Articles: 213

Full Length Research Paper

Study of some environmental and genetic determinants of autism in Egyptian children

  El Sawy MA1, Awadalla HI2*, Mohamed RR3, Zaki OK4 and Mohamed OA5
  1Genetics Unit and Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 2Medical Science Department, Institute of Environmental Studies and Research, Ain Shams University, Cairo, Egypt. 3New Renewable Institute of Energy and Electricity, Medical Department, Ain Shams University, Cairo, Egypt. 4Genetic Unit, Ain Shams University Hospital, Cairo, Egypt. 5Department of Medical Studies, Institute of Post Graduate Childhood Studies, Ain Shams University, Cairo, Egypt.    
Email: [email protected]

  •  Accepted: 21 July 2011
  •  Published: 30 November 2011



Autism is a neuro-developmental disorder of unknown cause. Both genetic and environmental influences are claimed to contribute to the etiology of autism. Several studies were done to determine the factors that contribute to the expression of the symptoms. We studied genetic, epigenetic and environmental factors that may influence the neurodevelopmental alteration that can cause vulnerability to autism. We did a controlled study on 44 patients who volunteered to participate at two Egyptian health clinics over 10 months duration. Full clinical evaluation, Cytogenetic analysis, biocard celiac test were done to detect anti-t TG Ig A antibodies for gluten sensitivity test; and quantase neonatal phenylalanine screening was done to detect the phenylalanine level in blood using ELISA. A part of significant positive family history, and no significant association were found between autism and the studied parameters. This study points to the important role of genetic susceptibility compared to the environmental factors and the role of family studies for determining the susceptible individuals to autism.


Key words: Autism, genetics and environmental interaction.