Full Length Research Paper
Abstract
In this study, the effects of aqueous root extract of Treculia africana on blood glucose, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol and body weights of both STZ-induced diabetic and normal rats were investigated. Oral administration of aqueous root extract of Treculia africanaat a dose of 200 mg/kg body weight per day, for a period of 14 days, caused a significant (p < 0.05) reduction in the blood levels of glucose, triglycerides, total cholesterol and LDL-cholesterol of both diabetic and normal rats. This dose also caused a significant (p < 0.05) increase in the HDL-cholesterol concentrations and body weights of both diabetic and normal rats. These effects portend the effectiveness of the plant in the management of diabetic conditions and hyperlipidemic states.
Key words: Streptozotocin (STZ), medicinal herbs, Treculia africana, lipid profile, hyperlipidemia, diabetes mellitus.
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