International Journal of
Physical Sciences

  • Abbreviation: Int. J. Phys. Sci.
  • Language: English
  • ISSN: 1992-1950
  • DOI: 10.5897/IJPS
  • Start Year: 2006
  • Published Articles: 2568

Full Length Research Paper

Cyclotron production of 89Zr: A potent radionuclide for positron emission tomography

M. Taghilo1, T. Kakavand 1*, S. Rajabifar2 and P. Sarabadani2  
1Department of Physics, Zanjan University, P. O. Box: 451-313, Zanjan, Iran. 2Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute. P.O. Box: 31485/498, Karaj, Iran.
Email: [email protected]

  •  Accepted: 15 February 2012
  •  Published: 30 March 2012

Abstract

In the present study, zirconium-89 (T1/2 = 3.27 day, Iβ+ = 23%, Eβ+ = 0.897 MeV) was produced through the 89Y(p,n) nuclear reaction at the Agricultural, Medical and Industrial Research School (AMIRS) Cyclotron (Cyclone-30, IBA, Belgium), irradiating Y2O3 with 15 MeV proton beam energy and 20 µA current for 20 min. The experimental yield of about 69.77 MBq 89Zr per µAh was obtained. The radiochemical separation of 89Zr from the irradiated Y2O3 target was done through the anion exchange chromatography with an overall of 95% process. The intended use of 89Zr is to label monoclonal antibodies (MoAbs) for tumor imaging using positron emission tomography (PET).

 

Key words: Anion exchange chromatography, production, zirconium-89, separation.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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