International Journal of
Physical Sciences

  • Abbreviation: Int. J. Phys. Sci.
  • Language: English
  • ISSN: 1992-1950
  • DOI: 10.5897/IJPS
  • Start Year: 2006
  • Published Articles: 2557

Full Length Research Paper

Inhibition of Lentinus edodes polysaccharides against liver tumour growth

Hong Fu, Wen-yuan Guo, Hao Yin, Zheng-xin Wang and Rui-dong LI*
Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China.
Email: [email protected]

  •  Accepted: 30 December 2010
  •  Published: 04 January 2011


The objective of this study was to examine the in vitro antitumour activities of Lentinus edodes polysaccharides. The present results demonstrated that L. edodespolysaccharides at 100 and 200 mg/kg dose-dependently suppressed liver tumour growth. The polysaccharides were still found to be dose-dependently and enhance spleen and thymus index and inhibit expression of Caspase-3 in mice with liver cancer. It may be concluded that L. edodes polysaccharides is beneficial to therapy of liver tumour.


Key words: Liver cancer, Lentinus edodes polysaccharides, caspase-3, spleen index.