Journal of
AIDS and HIV Research

  • Abbreviation: J. AIDS HIV Res.
  • Language: English
  • ISSN: 2141-2359
  • DOI: 10.5897/JAHR
  • Start Year: 2009
  • Published Articles: 283

Full Length Research Paper

Are first line anti-retroviral therapies really toxic for children? A study from Eastern India

Sayan Chatterjee
  • Sayan Chatterjee
  • Paediatrics Medicine, Midnapore Medical College and Hospital, Midnapore, India.
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Some Suvra Bose
  • Some Suvra Bose
  • Paediatric Medicine, Calcutta Medical College and Hospital, Kolkata, India.
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Bidyut Khuntdar
  • Bidyut Khuntdar
  • Paediatrics Medicine, Midnapore Medical College and Hospital, Midnapore, India.
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Subhasish Bhattacharya
  • Subhasish Bhattacharya
  • Paediatric Medicine, Calcutta Medical College and Hospital, Kolkata, India.
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  •  Accepted: 29 August 2012
  •  Published: 30 September 2012

Abstract

This research aims to study the incidence of drug induced toxicity during antiretroviral therapy (ART) among children from a tertiary care institute from Kolkata. This is a prospective study that consist of 100 children aged 2 to 14 years receiving first line ART [Stavudine (d4T), Lamivudine (3TC), Nevirapine (NVP)/Efavirenz (EFV)]; these children were followed up for 3 years (2007 to 2010).  The results showed gastro-intestinal symptoms in 20% (n = 20), transient maculo-papular skin rashes in 10% (n = 10), clinical jaundice in 4% (n = 4) and peripheral neuropathy in 1% (n = 1). No death or life threatening conditions like Steven-Johnson syndrome, immune reconstitution syndrome (IRIS), acute fulminant hepatitis and pancreatitis were noted. d4T, 3TC and NVP/EFV are safe in HIV positive children even after 3 years of uninterrupted ART. 

 

Key words: Human immunodeficiency virus (HIV), highly active anti retroviral therapy (HAART), fixed dose combination (FDC).