Journal of
AIDS and HIV Research

  • Abbreviation: J. AIDS HIV Res.
  • Language: English
  • ISSN: 2141-2359
  • DOI: 10.5897/JAHR
  • Start Year: 2009
  • Published Articles: 299

Full Length Research Paper

Assessment of the effect of anti-retroviral therapy on haematological parameters in HIV positive individuals in Zaria

E. M. Kayode
  • E. M. Kayode
  • Institute of Human Virology Nigeria, Jos Plateau State, Nigeria.
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D. O. Usiegbodi
  • D. O. Usiegbodi
  • Family Medicine Practice Centre, Gawu-Babangida Niger State Nigeria.
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M. E Ajiboye
  • M. E Ajiboye
  • Department of Haematology, Ahmadu Bello University Teaching Hospital (ABUTH) Shika, Zaria, Kaduna State, Nigeria.
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I. S.Omonye
  • I. S.Omonye
  • Department of Nursing, Alysia Caring Cambridgeshire United Kingdom.
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M. N. Febut
  • M. N. Febut
  • Africa Centre of Excellence in Phytomedicine Research and Development, University of Jos Plateau State, Nigeria.
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A. S. Buru
  • A. S. Buru
  • Genomic Research Laboratory, Department of Medical Microbiology and Parasitology, Faculty of Clinical Sciences, College of Medicine, Kaduna State University, Kaduna, Nigeria.
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  •  Received: 10 June 2018
  •  Accepted: 25 October 2019
  •  Published: 31 August 2020


Abdulqadir I, Ahmed SG, Kuliya AG, Tukur J, Yusuf AA, Musa AU (2018). Hematological parameters of human immunodeficiency virus positive pregnant women on antiretroviral therapy in Aminu Kano Teaching Hospital Kano, North Western Nigeria. Journal of Laboratory Physicians 10:60-63.


Ako SE, Njunda LA, Akum EA, Benjamin PT, Assob JC, Enoh JE, Bernard W, Fabrice NG (2018). Immuno-hematological Profile Trends of HIV/AIDs Patients on HAART in the South West Region of Cameroon: Retrospective Medical Report Review for Possible Stratified follow-up Pattern in Low Income Settings. American Journal of Microbiological Research 6(2):47-56.


Aurpibul L, Puthanakit T, Sirisanthana T, Sirisanthana V (2008). Haematological changes after switching from stavudine to zidovudine in HIV-infected children receiving highly active antiretroviral therapy. HIV Medicine 9(5):317-321.


Balakrishnan A, Valsalan R, Sheshadri S, Pandit VR, Medep V, Agrawal RK (2010). Zidovudine-induced reversible pure red cell aplasia. Indian Journal of Pharmacology 42:189-191.


Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK, Panel on Clinical Practices for Treatment of HIV (2002). "Guidelines for using antiretroviral agents among HIV-infected adults and adolescents" Annals of Internal Medicine.137:381-433.


Ebonyi AO, Oguche S, Ochoga MO, Agbaji OO, Anejo-Okopi JA, Abah IO, Okonkwo PI, Idoko JA (2017). Changes in the haematological parameters of HIV-1 infected children at 6 and 12 months of antiretroviral therapy in a large clinic cohort, North-Central Nigeria. Journal of Virus Eradication 3(4):208-211.


Ejele OA, Erhabor CA, Nwauche A (2004). Haematologic effects of some antiretroviral drugs in patients with AIDS. Sahel Medical Journal 8:25-29.


EMA (2015). Lamivudine/Zidovudine, Teva, INN-lamivudine/zidovudine.



Enawgaw B, Alem M, Addis Z, Melku M (2014). Determination of hematological and immunological parameters among HIV positive patients taking highly active antiretroviral treatment and treatment naive in the antiretroviral therapy clinic of Gondar University Hospital, Gondar, Northwest Ethiopia: a comparative cross-sectional study. BMC Hematology 14:8.


Gebremedhin KB, Haye TB (2019). Factors Associated with Anemia among People Living with HIV/AIDS Taking ART in Ethiopia Advances in Hematology 2019.


Gumel SD, Ibrahim A, Olayinka AT, Ibrahim MS, Balogun MS, Dahiru A, Ajayi I, Ajumobi O, Ahmadu I, Song A, Maifada AI, Abdullahi H (2019). HIV-malaria co-infection and its determinants among patients attending antiretroviral treatment clinic in Zaria, North-Western Nigeria. BioRxiv 588855


Idowu CO, Oke OT, Afolayan DO, Olaniran O, Akinloye OA, Awodumila OO (2013). Effect of HAART on some haematological parameters, correlations between total lymphocyte and CD4 counts of HIV clients attending ssh, Ikole-Ekiti. International Journal of Biological and Medical Research 4(3):3265-3270.


Ifeanyichukwu OM, Bright EO (2016). Effect of HIV infection on some haematological parameters and immunoglobulin levels in HIV patients in Benin City, Southern Nigeria Journal of HIV and Retro Virus 2:2.


Jacobson MA, Periperl L, Volberding PA, Porteous D, Toy PT, Feigal D (1990). Red Cell Transfusion Therapy for anaemia in patients with AIDS and ARC: incidence associated factors and outcome Transfusion 30:133.


Kofu K, Gresham-Dame GM, Peters M (1992). Rapid spread of HIV infection in Abidjan, Ivory Coast. European Journal of Clinical Microbiology and Infectious Diseases 11(27):1-3.


Kwame WO, Edzeamey FJ, Dompreh A, Gborgblorvor D, Awuah M, Ako AK, Asamoah GD (2018). Correlation of Hematological Parameters with TNF-α and Interleukin (IL-6) in Seropositive HIV Patients on Highly Active Antiretroviral Therapy (HAART) and HAART Naïve Patients. International Journal of Research and Reports in Hematology 1(1):1-7


Nacoulma EW, Some Y, Tieno H, Diallo I, Zoungrana A, Bougnounou R, Ouédraogo C, Drabo J, Guiard-Schmid JB (2007). Haematological parameters evolution during the antiretroviral therapy of HIV infected patients in Burkina-Faso]. Bulletin de la Societe de pathologie exotique 100(4):271-274.


Obiomah CF, Obeagu EI, Ochei KC, Swem CA, Amachukwu BO (2018). Haematological Indices of HIV Seropositive Subjects at Nnamdi Azikiwe University Teaching Hospital (Nauth), Nnewi. Annals of Clinical and Laboratory Research 6(1):221.


Odunukwe N, Idigbe O, Kanki P, Adewole T, Onwujekwe D, Audu R, Onyewuche J (2005). Haematological and biological response to HIV-1 infection with combination of nevirapine + stavudine + lamivudine in Lagos Nigeria. Turkish Journal of Haematology 22(3):125-131.


Osaro E, Emmanuel KU, Osekhuiemen AE, Confidence W (2009). Effect of long-term highly active antiretroviral therapy (HAART) on some haematological parameters of HIV-infected Nigerians. Heama 9(1):107-113. 


Sathiyavathi S, Pugazhendy K (2014). Assessments of haematological parameters in hiv patients present in and around salem district tamilnadu, India. International Journal of Modern Research and Reviews 2(11):501-504.


Scadden DT, Zeira M, Woon A, Wang Z, Schieve L, Ikeuchi K, Lim B, Groopman JE (1990). Human immunodeficiency virus infection of human bone marrow fibroblast. Blood 76:317.


Sheela Devi CS, Suchitha S, Gupta M (2016). A study of hematological profile in human immune deficiency virus infection: Correlation with CD4 counts. Annals of Pathology and Laboratory Medicine 3:484-489.


Swati K, Permeet Kaur B, Sita M (2016). Hematological manifestations in HIV infected patients and correlation with CD4 Counts and anti-retroviral therapy. International Journal of Contemporary Medical Research 3(12):3495-3498.


Taha TE, Kumwenda N, Gibbons A, Hoover D, Lema V, Fiscus S, Broadhead R (2002). Effect of HIV-1 antiretroviral prophylaxis on hepatic and hematological parameters of African infants. AIDS 16(6):851-858.


Umar RA, Ladan MJ, Hassan SW, Sa'id Y, Abbas AY, Oduolisaeme IB (2007). Administration of antiretroviral drugs (Lamivudine, Nevirapine and Stavudine) has no untoward effect on haematological profile in albino rats. Asian Journal of Biochemistry 2:147-151.


Zerihun KW, Bikis GA, Muhammad EA (2019). Prevalence and associated factors of anemia among adult human immune deficiency virus positive patients on anti-retroviral therapy at Debre Tabor Hospital, Northwest Ethiopia. BMC Research Notes 12(1):168.