Background: The disease of urinary tract and kidney results formation of calculi or stone known as urolithiasis. It is caused by missense mutation in adenine phosphoribosyltransferase enzyme, encoded by APRT gene.
Objective: In this paper comparative study of effectiveness of chemical constituents of synadenium grantii for treatment of urolithiasis was analyzed by docking approach.
Method: For this purpose the effective seven chemical constituents of synedium grantii were selected, downloaded and docked with APRT. The interactions of chemical constituent with APRT were analyzed by docking. The selected seven chemical constituents were phorbol ester, terpene, triterpene, flavonoid, tannin, coumorine, and anthraquinone. All these chemical constituents have anti-urolithiatic activity and used to treat Urolithiasis.
Results: This study reveals the interacting amino acid residues that have not been reported yet. Comparative analysis shows that out of seven constituents phorbol ester, triterpene, terpene and flavanoid were more effective for treatment of urolithiasis that show equal effectiveness. The results show that anthraquinone was least effective followed by coumarine and tannin.
Conclusion: This study shows that out of seven constituent’s phorbol ester, triterpene, terpene and flavanoid fond to be most effective for treatment of urolithiasis.
Keywords: Urolithiasis, Docking, APRT, Synedium grantii, Chemical constituents