Journal of
Bioinformatics and Sequence Analysis

  • Abbreviation: J. Bioinform. Seq. Anal.
  • Language: English
  • ISSN: 2141-2464
  • DOI: 10.5897/JBSA
  • Start Year: 2009
  • Published Articles: 46

Table of Content: June 2010; 2(2)

June 2010

Structural characterization of pfSerine hydroxymethyltransferase: A novel target for malaria

  New chemotherapeutic targets are urgently required to control malaria, a tropical disease caused by Plasmodium sp., which has been haunting mankind for ages. Serine hydroxymethyltransferase (SHMT) plays a major role in DNA biosynthesis.PfSHMT sequence compared for identities with hu mtSHMT (2A7V), T.ThHb8SHMT (2DKJ) and Rabbit cytSHMT (1EQB). ClustralW and Modeller9v3 were used for multiple...

Author(s): Rajasekhar Chikati, C. M. Anuradha, M. Chaitanya, B. Babajan, P. Yogi Prasad and Chitta Suresh Kumar.

June 2010

QPSOBT: One codon usage optimization software for protein heterologous expression

  QPSOBT is a codon usage optimization software based on the Quantum-behaved Particle Swarm Optimization (QPSO) algorithm. It can design synthetic genes of multikilobase sequences for protein heterologous expression rapidly. The program runs on .NET platform. Compared to the existing codon optimization software and web services, QPSOBT is able to generate better results when DNA/RNA sequence length is less than...

Author(s): Yujie Cai, Jun Sun, Jie Wang , Yanrui Ding, Xiangru Liao and Wenbo Xu