September 2017

Extrapolating human toxicity data with target organ dose (TOD-Wb) model: A meso-scale allometric analytical approach

An allometric target organ dose model (TOD-Wb) with variable scaling exponent, b = br + bo(bm) - bi, is proposed for the extrapolation of animal toxicity to human. The exponent b comprises four constituent parameters representing the intake mode to entry organ (bi), route of transportation to target organ (br), mass of target organ (bo), and rate of metabolism at target organ (bm). This expression enables the a priori...

Author(s): Swee-Cheng FOO, Ivan Siang-Meng SIN, Hui-Fang ANG and Rachel Qian-Yun CHE