Journal of
Cell and Animal Biology

  • Abbreviation: J. Cell Anim. Biol.
  • Language: English
  • ISSN: 1996-0867
  • DOI: 10.5897/JCAB
  • Start Year: 2007
  • Published Articles: 262

Full Length Research Paper

Effects of Aflatoxin B1 on the skeletal system of rabbit (Oryctolagus cuniculus) fetuses

S. M. El-Nahla
  • S. M. El-Nahla
  • Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
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H. M. Imam
  • H. M. Imam
  • Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
  • Google Scholar
E. A. Moussa
  • E. A. Moussa
  • Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
  • Google Scholar
A. R. Ghanam*
  • A. R. Ghanam*
  • Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
  • Google Scholar


  •  Received: 05 August 2014
  •  Accepted: 27 August 2014
  •  Published: 31 August 2014

References

Ampuja M1, Jokimäki R, Juuti-Uusitalo K, Rodriguez-Martinez A, Alarmo EL, Kallioniemi A (2013). BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment. BMC Cancer 13:429.
Crossref
 
Argyrous G (2005). Statistics for Research with a guide to SPSS, 2, Sage Publications, London
 
Arora RG (1982). Mycotoxin induced effects on the prenatal devel-opment in mice:a teratopathologic and autoradiographic study ofaflatoxin B1, ochratoxin Aand zearalenone. Ph.D. Thesis. Swedish University of Agricultural Sciences, Uppsala, Sweden.
 
Beaudion S, Barbet P, Bargy F (2003). Developmental Stages in the Rabbit Embryo: Guidelines to Choose an Appropriate Experimental Model. Fetal. Diagn. Ther.18:422-427.
Crossref
 
Brekhman V1, Neufeld G (2009). A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion. BMC Cancer 9:415.
Crossref
 
Brendel R, Duhamel KC, Shepard TH (1989):Embryotoxic drugs. Biol. Res. Preg. 6(1):1-54.
 
Buening MK, Fortner JG, Kappas A, Corney AH (1978). 7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver. Biochem. Biophys. Res. Commun. 82(1):348-55.
Crossref
 
Clark JD, Jain AV, Hatch RC, Mahaffey A (1980). Experimentally induced chronic aflatoxicosis in rabbits. Am. J. Vet. Res. 41:184-1845.
 
Decad GM, Hsieh DP, Byard JL (1977). Maintenance of cytochrome P-450 and metabolism of aflatoxin B1 in primary hepatocyte cultures. Biochem. Biophys. Res. Commun. 78(1):279-87.
Crossref
 
Diekman MA, Green ML (1992). Mycotoxins and reproduction in domestic livestock. Anim. Sci. 70:1615-1627.
 
El-Tahan AS (2013). A study on the effects of mycotoxins on pregnant rats. Master thesis, Faculty of Veterinary Medicine, Suez Canal University, Pathology department.
 
Foote RH, Carney EW(2000). The rabbit as a model for reproductive and developmental toxicity studies. Reprod. Toxicol.14: 477–493.
Crossref
 
Forrester LM, Neal GE, Judah DJ, Glancey MJ, Wolf CR (1990). Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver. Proc. Natl. Acad. Sci. USA 87(21):8306-10.
Crossref
 
Hsieh PH, Wong JJ (1994). Pharmacokineticsand excretion of aflatoxins. In: DL Eaton and JD Groopman (ed.), The toxicology ofaflatoxins: human health, veterinary,And agricultural significance. Academic Press, San Diego, California. pp. 73-88.
Crossref
 
Hussein HS, Brasel JM (2001). Toxicity, metabolism and impact of mycotoxins on human and animals. Toxicology 167:101-134.
Crossref
 
Inouye M (1976). Differential staining of cartilage and bone in fetal mouse skeleton byalcian-blue and alizarin red. S. Cong. Anom. 16:171-3.
 
Kärenlampi SO(1987). Mechanism of cytotoxicity of aflatoxin B1: role of cytochrome P1-450. Biochem Biophys Res Commun. 145(2):854-60.
Crossref
 
Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R, Judah DJ, Neal GE, Hayes JD (2000). Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. Cancer Res. 60(4):957-69.
 
Le Breton E, Fragssinet C, Lafarg C, De Recondo AM (1964). Aflatoxin. Mechanisme de faction. Food Cosmet. Toxicol. 2: 675–677.
 
Long F, Ornitz DM (2013). Development of the endochondral skeleton. Cold Spring Harb. Perspect. Biol. 5(1):a008334.
Crossref
 
Marquardt RR, Frohlich AA (1992). A review of recent advances in understanding ochratoxicosis. J. Anim. Sci. 70:3968-3988.
 
Nomina Anatomica Veterinaria (2005). 5th Ed. Prepared by International Committee on Veterinary Gross Anatomical Nomenclature (I. C.V.G.A.N) and authorized by the General Assembly of the World Association of Veterinary Anatomists(W. A. V.A),Konxiville, TN, USA.
 
Nomina Embryologica Veterinaria (2003). 2nd Edition. International Committee on Veterinary Gross Embryological Nomenclature (I. C.V.E.N) and authorized by general assembly of the world association of Veterinary Anatomists (W.A.V.A) Konxiville, TN, USA.
 
Oh JH, Park SY, de Crombrugghe B, Kim JE (2012). Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification. Biochem. Biophys. Res. Commun. 418(4):634-40.
Crossref
 
Orsi RB, Oliveira CAF, Dilkin P, Yavie JG, Direitio GM, Correa B (2007). Effects of oral administration of aflatoxin B1 and fumonisin B1 in rabbits. Chem. Biol. Interact. 170:201-208
Crossref
 
Petrere JA, Rohn WR, Grantham LE, Anderson JA (1993). Food restriction during organogenesis in rabbits: effects on reproduction andthe offspring. Fundam. Appl. Toxicol. 21:517-522.
Crossref
 
Pier AC (1992). Major biological consequences of aflatoxicosis in animal production. Anim. Sci. 70:3964-3967.
 
Reddy G, Rao DGK (2001). Teratological effects of aflatoxin in rabbits. Ind. Vet. 78:900-902.
 
Sharma A, Sahai R (1987). Teratological effects of aflatoxin on rats (Rattusnovegocus). Ind. J. Anim. Res. 21 (1):35-40.
 
Stanley FC, Bower C (1986). Teratogenic drugs in pregnancy. Med. J. Aust. 11–12(145):596–9.
 
Tashiro F, Morimura S, Hayashi K, Makino R, Kawamura H, Horikoshi N, Nemoto K, Ohtsubo K, Sugimura T, Ueno Y (1986). Expression of the c-Ha-ras and c-myc genes in aflatoxin B1-induced hepatocellular carcinomas. Biochem. Biophys. Res. Commun. 138(2):858-64.
Crossref
 
Trail F, Mahanthi N, Linz J (1995). Molecular biology of aflatoxin biosynthesis. Microbiology 141 (4):755-765.
Crossref
 
Vickers M, Brackley K (2002). Drugs in pregnancy. Curr. Obstet. Gynaecol. 12:131–7.
Crossref
 
Wangikar PB, Dwivedi P, Sinha N (2004b). Effects in rats of simultaneous prenatal exposure to ochratoxin A andaflatoxin B1.I. Maternal toxicity and fetal anomalies. Birth Defects Res. B Dev. Reprod. Toxicol. 71 (6):343-351.614.
 
Wangikar PB, Dwivedi P, Sharma AK, Sinha N (2005). Effects of aflatoxin B1on embryo fetal development in rabbits. Food Chem. Toxicol. 43:607–615.
Crossref
 
Wangikar PB, Dwivedi P, Sharma AK, Telang AG, Bisht GS (2004a). Haemato-biochemical changes in experimental ochratoxicosis andaflatoxicosis alone and in combination in pregnant rabbits. Ind. J. Vet. Pathol. 28 (1): 64-67.
 
Weber FE, Eyrich G, Grätz KW, Thomas RM, Maly FE, Sailer HF (2001). Disulfide bridge conformers of mature BMP are inhibitors for heterotopic ossification. Biochem. Biophys. Res. Commun. 286(3):554-8.
Crossref
 
World Health Organization, International Agency for Research on Cancer (IARC) (1993). Monographs on evaluation of carcinogenic risks to humans
 
Wuelling M, Vortkamp A (2011). Chondrocyte proliferation and differentiation. Endocr. Dev. 21:1.
Crossref
 
Yoshida GJ, Saya H, Zouboulis CC (2013). Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling. Biochem. Biophys. Res. Commun. 438(4):640-6.
Crossref
 
Yoshizawa H, Uchimaru R, Ueno Y (1981). Metabolism of aflatoxin B1 in the isolated nuclei of rat liver. J. Biochem. 89(2):443-52.
PMid:6787032
 
Young AD, Phipps DE, Astroff AB (2000). Large-scale double staining of rat fetal skeletons using alizarin red S and alcian blue.Teratology 61:273-6.
Crossrefht