September 2011

Using the ant colony optimization algorithm in the network inference and parameter estimation of biochemical systems

Developing models that can represent biochemical systems is one of the hallmarks of systems biology. Scientists have been gathering data from actual experiments, but there is a lack in computer models that can be used by scientists in analysing the various biochemical systems more effectively. In this research, we propose to use an ant colony optimization (ACO) algorithm for the network inference and parameter...

Author(s): Philip Christian C. Zuniga

September 2011

Functional equivalence between plant PRORP1 and bacterial RNase P Ribonucleic acid (RNA) raises questions on control and recognition mechanisms

In this short communication we consider the recent results of the successful substitution of theEscherichia coli RNase P ribonucleic acid (RNA) with the Arabidopsis protein enzyme PRORP1. The interest of this result lies in the fact that a plant protein-only enzyme is able to rescue lethal knock-down of the RNA component of bacterial RNase P. Such findings raise interesting questions as well as...

Author(s): Gennaro Auletta, Ivan Colagè, Geoffrey Cook, Paolo D’Ambrosio, Miguel Ramón and Andrew Pinsent