Journal of
Clinical Medicine and Research

  • Abbreviation: J. Clin. Med. Res.
  • Language: English
  • ISSN: 2141-2235
  • DOI: 10.5897/JCMR
  • Start Year: 2009
  • Published Articles: 103

Full Length Research Paper

Comparative in vitro potency of four fluoroquinolones on clinical isolates over a year period

Oyinloye J. M. Adedeji
  • Oyinloye J. M. Adedeji
  • Department of Biological Sciences, Afe Babalola University Ado Ekiti, Nigeria.
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Otuneme Oluchi
  • Otuneme Oluchi
  • Department of Biosciences and Biotechnology, Babcock University, Nigeria.
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Akeredolu A. A.
  • Akeredolu A. A.
  • Department of Biosciences and Biotechnology, Babcock University, Nigeria.
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Ezekiel C. N.
  • Ezekiel C. N.
  • Department of Biosciences and Biotechnology, Babcock University, Nigeria.
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Babalola B. Teniola
  • Babalola B. Teniola
  • Department of Mathematical and Physical Sciences, Afe Babalola University Ado Ekiti, Nigeria.
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Obebe Olusola O.
  • Obebe Olusola O.
  • Department of Veterinary Microbiology and Parasitology, University of Ibadan, Ibadan, Oyo State Nigeria.
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Nwadike Faith U.
  • Nwadike Faith U.
  • Department of Biosciences and Biotechnology, Babcock University, Nigeria.
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Alatise Folasade A.
  • Alatise Folasade A.
  • Department of Biosciences and Biotechnology, Babcock University, Nigeria.
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  •  Accepted: 16 December 2013
  •  Published: 31 January 2014

Abstract

This study aimed at evaluating the efficacy of four common fluoroquinolone drugs over a year period on some clinical isolates. It also aimed at comparing statistically the average effects of each drug on the isolates. Five different clinical samples (urine, sputum, wound, blood and high vaginal swab [HVS]) from patients attending a university medical centre (between June 2011 and May 2012) were analysed for the purpose of bacteria isolation. The isolates were tested with commonly used flouroquinolones: pefloxacin (30 µg), ofloxacin (30 µg), sparfloxacin (10 µg), and ciprofloxacin (10 µg). Each sensitivity test was done in duplicate and a mean average of zone of inhibition was recorded. One hundred and eighty eight bacteria were isolated: Staphylococcus aureus (44.7%), Streptococcus pyogenes (6.4%), Escherichia coli (28.2%), Pseudomonas aeruginosa (8.5%), Klebsiella pneumonia (8.0%), and Proteus mirabilis (4.3%). All drugs were equally potent against the isolates, but a higher potency was seen in ofloxacin against P. mirabilis. The fluoroquinolones are a group of broad spectrum drugs effective in clinical cases. Their efficacy should be preserved by ensuring strict compliance to local drug policies.

Key words: Clinical, fluoroquinolones, efficacy.