Journal of
Infectious Diseases and Immunity

  • Abbreviation: J. Infect. Dis. Immun.
  • Language: English
  • ISSN: 2141-2375
  • DOI: 10.5897/JIDI
  • Start Year: 2009
  • Published Articles: 87

Full Length Research Paper

Oral lesions and systemic diseases in HIV-infected subjects

Maria Sueli Marques Soares*, Dayane Franco Barros Mangueira Leite, Rachel Reinaldo Arnaud, Francisco Diogo Carrilho Oliveira Filho, Alysson Marconni Holanda Lima, Douglas Savio de Sousa and Moizes Alves de Lima Segundo
Department of Clinical and Social Dentistry, Federal University, João Pessoa, Paraíba, Brazil.
Email: [email protected]

  •  Accepted: 23 August 2011
  •  Published: 29 September 2011


The aim of this study was to determine the prevalence of oral lesions and systemic diseases in HIV- infected subjects and to assess possible relationship between them. This was a cross-sectional analytical study. Oral examination was performed in HIV-infected adult individuals. CD4+ count and viral load were recorded and systemic diseases classified. The most common oral lesions were oral candidiasis (26.8%), oral hairy leukoplakia (7.3%) and salivary gland enlargement (6.1%), and systemic diseases were diarrhea (36.6%), HPV infection (24.4%), genital herpes (18.3%), gonorrhea (14.6%), herpes zoster virus infection (13.4%), toxoplasmosis (13.4%) and syphilis (12.2%). A significant association was found between oral lesions and systemic diseases (p = 0.005) and particularly with diarrhea (p = 0.010). There was a significant association between oral candidiasis and systemic diseases (p = 0.030), STDs (p = 0.039), diarrhea (p = 0.023), Pneumocytis jiroveci pneumonia (p=0.014) and furunculosis (p = 0.014). The results indicate high prevalence of oral lesions in conjunction with similar prevalence of systemic diseases; oral candidiasis and systemic infections were noted especially.


Key words: AIDS, oral candidiasis, systemic disease.