Journal of
Infectious Diseases and Immunity

  • Abbreviation: J. Infect. Dis. Immun.
  • Language: English
  • ISSN: 2141-2375
  • DOI: 10.5897/JIDI
  • Start Year: 2009
  • Published Articles: 94

Article in Press

Molecular mechanism of Clofazimine resistance in tuberculosis

Mst Sumaia Khatun 1, Sadia Afrin2*, Md Shah Alam 3, 4*

  •  Received: 27 February 2020
  •  Accepted: 09 June 2020
Drug resistance which is at present main impendence to global tuberculosis (TB) control and drug-resistant (DR) activity of Mycobacterium tuberculosis (M. tuberculosis) in various strains have become the major challenge worldwide. Nowadays many researchers used different antibiotics for treatment of DR-TB are often unwell tolerated and not adequately efficient. A large group study from various research published in different time described a treatment regimen for multidrug-resistant tuberculosis (MDR-TB) including Clofazimine (CFZ) as being highly incidence against MDR-TB. Whereas the therapeutic ways are still limited, the main strategy for treatment of DR-TB is to repurpose existing anti-mycobacterial agents. Clofazimine (CFZ) is one such drug that has recently devoted interest against DR-TB. Clofazimine (CFZ) is a fat-soluble riminophenazine dye used in the treatment of TB, HIV, and leprosy co-infected people worldwide. Clofazimine has shown action against MDR TB and which is now recommended by the WHO to treat drug resistant tuberculosis as a therapeutic agent with “unclear efficacy”. Although the mode of action and molecular mechanism of CFZ are not yet entirely understood, it has been exposed that outer membrane is its primary action site, an extensive number of mutant resistant to clofazimine and found mutations in rv0678 to be the most prominent mechanism of clofazimine resistance and the respiratory chain and ion transporters are the putative targets. After all in this review study, we will discuss the comprehensive report, action and molecular reactivity of CFZ, and provide new acuteness into the clinical conduct of this drug.

Keywords: Clofazimine, Background, mode of action, molecular mechanism