Journal of
Microbiology and Antimicrobials

  • Abbreviation: J. Microbiol. Antimicrob.
  • Language: English
  • ISSN: 2141-2308
  • DOI: 10.5897/JMA
  • Start Year: 2009
  • Published Articles: 160

Full Length Research Paper

Biochemical role of nitric oxide precursor and antibiotic against typhoid

S. S. Haque
Department of Clinical Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India.
Email: [email protected]

  •  Accepted: 17 June 2011
  •  Published: 30 August 2011



      Typhoid fever remains an underestimated important health problem in many developing countries. It continues to be a global problem with an annual estimate of 1.6 million cases and 600,000 deaths. Salmonella, gram negative bacilli can survive during certain stages of host parasites interaction. There are number of drugs being used for the treatment of typhoid, but increasing occurrence of multidrug resistant (MDR) strain of Salmonella typhi has complicated its management, that thus, it has necessitated the search of formulated drugs for its treatments. Nitric oxide (NO) is a versatile molecule produced in a biological system. Previous studies have suggested that exogenous administration of L-arginine results in increased NO production, indicating that endogenous substrate is insufficient for maximal NO production. Taking these facts in to consideration, it was thought pertinent to see the effect of oral administration of NO precursor that is, L-arginine. Formulation of nitric oxide precursor and antibiotics shows decreases in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) by 54.24% and 53.91% in 1/2 LArg+1/2 Cip group as compared to bacterial treated groups.


Key words: Salmonella typhi, L-arginine, ciprofloxacin, alanine aminotransferase (ALT), aspartate aminotransferase (AST).


NO, Nitric oxide; MDR, multidrug resistant; ALT, alanine aminotransferase.